Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates - Test2 - elhamkhani - TriplyDB

Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates

Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates

http://www.wikidata.org/entity/Q24645055

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Fine-tuning multiprotein complexes using small molecules Mechanisms of protein-folding diseases at a glance Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design Therapeutic target-site variability in α1-antitrypsin characterized at high resolution In silico assessment of potential druggable pockets on the surface of α1-antitrypsin conformers Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency.The flexible pocketome engine for structural chemogenomics.Small Molecule Probes That Perturb A Protein-protein Interface In Antithrombin Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency.Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis Stem cell-based therapy for α₁-antitrypsin deficiency A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity Embelin binds to human neuroserpin and impairs its polymerisation.Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype.Molecular Mechanism of Z α1-Antitrypsin Deficiency Polymers and inflammation: disease mechanisms of the serpinopathies alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.α1-antitrypsin Deficiency: A Misfolded Secretory Protein Variant with Unique Effects on the Endoplasmic Reticulum.Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease.Augmentation therapy in alpha-1 antitrypsin deficiency: advances and controversies.Emerging drugs for alpha-1-antitrypsin deficiency.α(1)-antitrypsin deficiency and inflammation.Unravelling the twists and turns of the serpinopathies.Twenty years of polymers: a personal perspective on alpha-1 antitrypsin deficiency.Recent advances in α-1-antitrypsin deficiency-related lung disease.Alpha-1 antitrypsin deficiency: new developments in augmentation and other therapies.Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models.An ECLIPSE View of Alpha-1 Antitrypsin Deficiency.Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization.An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein.Mechanisms underlying the cellular clearance of antitrypsin Z: lessons from yeast expression systems.1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin Electrophoresis- and FRET-Based Measures of Serpin Polymerization.Liver Disease in Alpha-1 Antitrypsin Deficiency: Current Approaches and Future Directions.The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency.α1-Antitrypsin deficiency.Molecular bases of neuroserpin function and pathology.

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P2860

Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates

http://www.wikidata.org/entity/Q24645055

description

2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007年の論文

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2007年論文

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2007年论文

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Small molecules block the poly ...... ce of intracellular aggregates

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Small molecules block the poly ...... ce of intracellular aggregates

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Small molecules block the poly ...... ce of intracellular aggregates

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Small molecules block the poly ...... ce of intracellular aggregates

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Small molecules block the poly ...... ce of intracellular aggregates

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Small molecules block the poly ...... ce of intracellular aggregates

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Small molecules block the poly ...... ce of intracellular aggregates

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Small molecules block the poly ...... ce of intracellular aggregates

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Small molecules block the poly ...... ce of intracellular aggregates

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Arash M Shirvani

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Bibek Gooptu

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Daniel J Termine

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David A Lomas

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Meera Mallya

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S Adrian Saldanha

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Sarah C Leigh Brown

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Ying Wu

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P2860

Structure of a serpin-protease complex shows inhibition by deformation

Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury

Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

Familial dementia caused by polymerization of mutant neuroserpin

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro

Association between conformational mutations in neuroserpin and onset and severity of dementia

Cavities of alpha(1)-antitrypsin that play structural and functional roles

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