Association between conformational mutations in neuroserpin and onset and severity of dementia - Test2 - elhamkhani - TriplyDB

Association between conformational mutations in neuroserpin and onset and severity of dementia

Association between conformational mutations in neuroserpin and onset and severity of dementia

http://www.wikidata.org/entity/Q28213399

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Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X An overview of the serpin superfamily Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin.Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.The tempered polymerization of human neuroserpin.A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.Protein misfolding and the serpinopathies.The endoplasmic reticulum (ER)-associated degradation system regulates aggregation and degradation of mutant neuroserpin.Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system.Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency.The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans.Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies.Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization.Alpha1-antitrypsin deficiency. 4: Molecular pathophysiology Identification of a neurovascular signaling pathway regulating seizures in mice Expression of SERPINA3s in cattle: focus on bovSERPINA3-7 reveals specific involvement in skeletal muscle.Embelin binds to human neuroserpin and impairs its polymerisation.What we owe to alpha(1)-antitrypsin and to Carl-Bertil Laurell.The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.Update on research, diagnosis and management of alphal-antitrypsin deficiency.Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.Hepatic fibrosis and carcinogenesis in α1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders.

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P2860

Association between conformational mutations in neuroserpin and onset and severity of dementia

http://www.wikidata.org/entity/Q28213399

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Association between conformati ...... onset and severity of dementia

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Association between conformati ...... onset and severity of dementia

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Association between conformati ...... onset and severity of dementia

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type

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Association between conformati ...... onset and severity of dementia

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Association between conformati ...... onset and severity of dementia

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Association between conformati ...... onset and severity of dementia

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prefLabel

Association between conformati ...... onset and severity of dementia

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Association between conformati ...... onset and severity of dementia

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Association between conformati ...... onset and severity of dementia

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Association between conformati ...... onset and severity of dementia

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Antony E Shrimpton

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Bernardino Ghetti

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Bruno Baumann

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Charles B Bradshaw

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Daniel A Lawrence

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Daria Larocca

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David A Lomas

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Felicitas Lacbawan

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George H Collins

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Lieselotte Gerhard

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2242-7

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scholarly article

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10.1016/S0140-6736(02)09293-0

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9325

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Maximilian Muenke

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2002-06-29T00:00:00Z

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