Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi - Test2 - elhamkhani - TriplyDB

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

http://www.wikidata.org/entity/Q24646052

about

Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP Germline mutations in BAP1 predispose to melanocytic tumors Analysis of the genome to personalize therapy for melanoma Frequent mutation of BAP1 in metastasizing uveal melanomas Mutations in GNA11 in uveal melanoma Oncogenic mutations in GNAQ occur early in uveal melanoma Metastatic disease from uveal melanoma: treatment options and future prospects Resistant mechanisms to BRAF inhibitors in melanoma Recent advances in molecular genetics of melanoma progression: implications for diagnosis and treatment Animal Models of Uveal Melanoma: Methods, Applicability, and Limitations Uveal melanoma as a target for immune-therapy Ocular diseases: immunological and molecular mechanisms Animal Eye Models for Uveal Melanoma Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition)Melanoma: oncogenic drivers and the immune system Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets Recent developments in prognostic and predictive testing in uveal melanoma The G protein α chaperone Ric-8 as a potential therapeutic target Melanoma: new insights and new therapies Pathways and therapeutic targets in melanoma Optimal management of metastatic melanoma: current strategies and future directions Evidence for the Role of Blue Light in the Development of Uveal Melanoma Emerging patterns of somatic mutations in cancer Melanoma: from mutations to medicine Metastatic uveal melanoma: biology and emerging treatments Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex Full-length Gαq–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis.Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition.Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial.BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells.Metabolic rewiring in melanoma Neurocutaneous Manifestations of Genetic Mosaicism

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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

http://www.wikidata.org/entity/Q24646052

description

2009 nî lūn-bûn

@nan

2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@ast

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@en

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@nl

type

label

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@ast

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@en

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@nl

prefLabel

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@ast

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@en

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

@en

P2093

Gary Green

http://www.w3.org/2001/XMLSchema#string

Gregory S Barsh

http://www.w3.org/2001/XMLSchema#string

Joan M O'Brien

http://www.w3.org/2001/XMLSchema#string

Lona Gaugler

http://www.w3.org/2001/XMLSchema#string

Vladimir Bezrookove

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations of the BRAF gene in human cancer

Two G protein oncogenes in human endocrine tumors

Effects of G-protein mutations on skin color

The temporal requirement for endothelin receptor-B signalling during neural crest development

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

Distinct sets of genetic alterations in melanoma

The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society.

High frequency of BRAF mutations in nevi.

Uveal melanoma: epidemiologic aspects.

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599-602

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scholarly article

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448329

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10.1038/NATURE07586

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P433

7229

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457

http://www.w3.org/2001/XMLSchema#string

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Elizabeth M Simpson

Boris C. Bastian

Catherine D Van Raamsdonk

P577

2009-01-29T00:00:00Z

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23659816

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1018711414

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19078957

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2696133

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