Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
about
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasisTrypanocidal activity of marine natural productsStructure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzymeChemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosomeAllosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralogA global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targetsMolecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetaseIdentification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic TrypanosomatidsPolyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesGenetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.Target validation: linking target and chemical properties to desired product profileHomoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40.Disclosing the essentiality of ribose-5-phosphate isomerase B in TrypanosomatidsProduct feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozymeEscherichia coli glutathionylspermidine synthetase/amidase: phylogeny and effect on regulation of gene expression.State of the art in African trypanosome drug discovery.Drug discovery for neglected diseases: molecular target-based and phenotypic approaches.Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase.Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes-A Quantitative Redox Proteome and Thiol Analysis.Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modelingMolecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathioneGenomics decodes drug action
P2860
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P2860
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Dissecting the essentiality of ...... g chemical and genetic methods
@ast
Dissecting the essentiality of ...... g chemical and genetic methods
@en
Dissecting the essentiality of ...... g chemical and genetic methods
@nl
type
label
Dissecting the essentiality of ...... g chemical and genetic methods
@ast
Dissecting the essentiality of ...... g chemical and genetic methods
@en
Dissecting the essentiality of ...... g chemical and genetic methods
@nl
prefLabel
Dissecting the essentiality of ...... g chemical and genetic methods
@ast
Dissecting the essentiality of ...... g chemical and genetic methods
@en
Dissecting the essentiality of ...... g chemical and genetic methods
@nl
P2093
P2860
P50
P3181
P1476
Dissecting the essentiality of ...... g chemical and genetic methods
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P2093
Daniel Spinks
Stephen Patterson
Stephen Thompson
P2860
P304
P3181
P356
10.1111/J.1365-2958.2009.06761.X
P407
P577
2009-11-01T00:00:00Z