The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
about
Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stressLAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasisEvidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlA mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alphaAssociation of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activationGenome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2pA multiplicity of coactivators is required by Gcn4p at individual promoters in vivoIfkA, a presumptive eIF2 alpha kinase of Dictyostelium, is required for proper timing of aggregation and regulation of mound sizeInterplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.The role of posttranslational modifications in the assembly of stress granulesBenefits of short-term dietary restriction in mammalsMetabolic remodeling in iron-deficient fungiAmino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TORNutrient-sensing mechanisms across evolutionSpatio-temporal Dynamics and Mechanisms of Stress Granule AssemblyProtective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and MammalsYIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.Amino acid-dependent Gcn4p stability regulation occurs exclusively in the yeast nucleus.Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain.Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1.Phosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae.Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-CTwo heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertionActivating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress responseKIS is a protein kinase with an RNA recognition motifAntiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA virusesTranscriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeastPfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvationTranslational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory.Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cellsActivation of stress response pathways promotes formation of antiviral granules and restricts virus replicationSelective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiaeTransfer RNA and human diseasetRNAs as regulators of biological processesSnf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.
P2860
Q22253195-DBCB0ADB-0DD5-44A1-8861-3D5CECC1808BQ24294168-1C9CC4FC-0D33-4994-ACFA-24B5F8D04E4CQ24319050-DA61D538-78B8-42F6-90EE-CCB34ABECA15Q24522941-4671D912-CF95-4BA8-9633-2F5CFFA28BE0Q24548092-1570C5FA-23E9-458D-8836-6AC33FD38735Q24600114-228E8C81-849F-4B74-9B20-FDC3649B0C48Q24657415-A942B200-30C8-48CA-8AD3-E57C7FB6B4A6Q24684851-0F98B810-F12D-49D2-8CDE-02856430D1DCQ24794392-350E2F84-2801-48C4-A234-050267BF660BQ24813138-8B8FD3FE-1293-4E06-BE2B-A8BE93CD32B3Q26825332-1E07596E-EF67-4B0D-8C87-9CFE4BE9D14DQ26830788-1C659F3B-BC86-412D-8DB9-D92AB5064498Q26858881-0BD901D0-A54A-4501-BB9A-9FEB91668702Q27001717-5EAED544-8937-475D-93CD-FB769CB96A56Q27015819-53A12BA9-9147-4345-B16E-C7C2CB811B7EQ27318590-6BA9AC67-8B78-4AF1-811F-060A5E5BB527Q27333486-1E539955-89B5-4078-917C-D3593A96387BQ27683181-5C32BD0F-13E2-40B8-B428-B3C023CF0D55Q27932122-649A79CC-2A8A-4C3C-A5F4-11B165AE8EC9Q27933307-3F60644C-8402-4EBF-82DC-1AAE5EA088F0Q27934914-46EDFFED-8A8D-47B1-A4D5-45D28D73E670Q27935862-2CF0506F-6537-481E-A0CC-C7AB603133E6Q27937295-678B5D4A-7497-4A56-BFF0-E46F0102F6D2Q27937914-7AAA0357-7947-4A43-862E-660751362B88Q27938904-79C0040A-93FA-4BDA-805E-50B933CEE72DQ27940265-D58675EF-E20D-4816-980E-39371F615C41Q28252951-EFAC0898-DA95-4953-82BC-F0F0BFF528C4Q28506814-D28433AD-A694-4670-A402-59FD9733F9D0Q28508156-79A83090-3DE6-4E30-B00E-36821D260990Q28574971-A8BD53DC-71FA-473E-A1B2-6D6B525A90E5Q28586515-2BCA1BCC-4EBF-4F54-BC9F-C53D729C4943Q29614487-029667E3-3A17-4F90-B6DF-5DE0DFEDC8D9Q30042894-E94C28C5-9383-448F-B2E8-1E5142B9C37FQ30429927-F4D2FC08-F0E6-4887-90E4-3FA1498479F9Q33583677-7D185DDB-F2D8-4BE6-82CF-20FCB59E665CQ33602629-5DE08C69-18A9-4A7A-9DAE-EE41D36CA7A7Q33649143-42F71C64-F8DE-47D0-808A-0AC2C5137B83Q33703946-6317CEA7-6C7D-4519-BBA5-BFF8B4920DC8Q33737299-03CE64EC-2D99-4267-A6B5-A187CAA95715Q33877596-1FA7FEDE-7D18-4C3B-9982-31CF36CEF749
P2860
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@ast
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@en
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@nl
type
label
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@ast
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@en
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@nl
prefLabel
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@ast
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@en
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@nl
P2093
P2860
P3181
P356
P1476
The histidyl-tRNA synthetase-r ...... tion for different amino acids
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.15.8.4497
P407
P577
1995-08-01T00:00:00Z