Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.
about
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinasePancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stressDimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stressNck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stressIdentification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlA mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alphaAssociation of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activationAn aminoacyl-tRNA synthetase paralog with a catalytic role in histidine biosynthesisDimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain.Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activityRibosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.Histidyl-tRNA synthetaseThe double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitroPhysical evidence for distinct mechanisms of translational control by upstream open reading framesActivating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress responseTranscriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeastEnhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cellsGCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration.Phosphorylation of the RNA-dependent protein kinase regulates its RNA-binding activity.Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.Cloning and characterization of a cDNA encoding a protein synthesis initiation factor-2alpha (eIF-2alpha) kinase from Drosophila melanogaster. Homology To yeast GCN2 protein kinase.Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation.Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.Phosphorylation of eIF2α via the general control kinase, GCN2, modulates the ability of renal medullary cells to survive high urea stress.Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.Rapid evolutionary adaptation to growth on an 'unfamiliar' carbon source.A yeast glutamine tRNA signals nitrogen status for regulation of dimorphic growth and sporulationSolution structure of the RWD domain of the mouse GCN2 proteinEukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation.A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death.Calcium channel regulator Mid1 links TORC2-mediated changes in mitochondrial respiration to autophagy.
P2860
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P2860
Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.
description
1996 nî lūn-bûn
@nan
1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@ast
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@en
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@nl
type
label
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@ast
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@en
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@nl
prefLabel
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@ast
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@en
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@nl
P2093
P2860
P3181
P356
P1476
Histidyl-tRNA synthetase-relat ...... itro phosphorylation of eIF-2.
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.271.40.24989
P407
P577
1996-10-04T00:00:00Z