Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
about
VHL type 2B mutations retain VBC complex form and functionFIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activityTIP120A associates with cullins and modulates ubiquitin ligase activityMammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulationThe forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanismMammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alphaVHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesBiochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasisAnalysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitinationHIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylationThe VHL tumor suppressor: master regulator of HIFIdentification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alphaHIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxiaThe VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activityVanadate-induced expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen speciesAnalysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissuesContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisThe Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and DiseaseUnderstanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironmentHypoxia and metabolic properties of hematopoietic stem cellsHypoxia and Integrin-Mediated Epithelial Restitution during Mucosal InflammationHIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogasterComputational and experimental characterization of dVHL establish a Drosophila model of VHL syndromeIntegrated molecular analysis of clear-cell renal cell carcinoma.Requirement of ELC1 for RNA polymerase II polyubiquitylation and degradation in response to DNA damage in Saccharomyces cerevisiaeIndependent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylationBinding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7Direct interactions between HIF-1 alpha and Mdm2 modulate p53 functionCarboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factorInduction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxiaIron regulation by hepcidinRole of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesisHypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alphaMitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
P2860
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P2860
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@ast
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@en
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@nl
type
label
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@ast
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@en
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@nl
prefLabel
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@ast
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@en
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@nl
P2093
P2860
P3181
P356
P1476
Activation of HIF1alpha ubiqui ...... (VHL) tumor suppressor complex
@en
P2093
J W Conaway
M Czyzyk-Krzeska
R C Conaway
P2860
P304
10430-10435
P3181
P356
10.1073/PNAS.190332597
P407
P577
2000-09-01T00:00:00Z