about
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationBruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding proteinp56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transductionThe zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding proteinIdentification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activationCrif1 is a novel transcriptional coactivator of STAT3Inhibition of Stat1-mediated gene activation by PIAS1Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 GagInteraction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptorDAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expressionTwenty proteins containing a C-terminal SOCS box form five structural classesVHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesAnkyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradationJAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase.Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor IIPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayInterleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signallingSocs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferationThe JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loopRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationStructural and functional insights into the B30.2/SPRY domain.Antiviral actions of interferonsFunctional analysis of Asb-1 using genetic modification in miceGRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interactionDifferential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbetaA Drosophila PIAS homologue negatively regulates stat92ECentral role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouseMast cell homeostasis and the JAK-STAT pathwayA DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/MThe conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationIdentification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexActivation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexEnhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptorCholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activationSignal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylationOverexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivationA novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland
P2860
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P2860
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A family of cytokine-inducible inhibitors of signalling
@ast
A family of cytokine-inducible inhibitors of signalling
@en
A family of cytokine-inducible inhibitors of signalling
@en-gb
A family of cytokine-inducible inhibitors of signalling
@nl
type
label
A family of cytokine-inducible inhibitors of signalling
@ast
A family of cytokine-inducible inhibitors of signalling
@en
A family of cytokine-inducible inhibitors of signalling
@en-gb
A family of cytokine-inducible inhibitors of signalling
@nl
prefLabel
A family of cytokine-inducible inhibitors of signalling
@ast
A family of cytokine-inducible inhibitors of signalling
@en
A family of cytokine-inducible inhibitors of signalling
@en-gb
A family of cytokine-inducible inhibitors of signalling
@nl
P2093
P3181
P356
P1433
P1476
A family of cytokine-inducible inhibitors of signalling
@en
P2093
B J Jenkins
D J Hilton
J R Rayner
L J Murray
N A Nicola
T A Willson
P2888
P304
P3181
P356
10.1038/43206
P407
P577
1997-06-26T00:00:00Z
P6179
1028197251