The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
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The UBL domain of PLIC-1 regulates aggresome formationAlzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formationUbiquilin functions in autophagy and is degraded by chaperone-mediated autophagyAccumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradationUbiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrinUbiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradationDimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilinsAffinity Makes the Difference: Nonselective Interaction of the UBA Domain of Ubiquilin-1 with Monomeric Ubiquitin and Polyubiquitin ChainsALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.Protein aggregation and degradation mechanisms in neurodegenerative diseasesThe emerging roles of microRNAs in the pathogenesis of frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum disordersSelective targeting of KRAS-mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-mutant cellsVWA domain of S5a restricts the ability to bind ubiquitin and Ubl to the 26S proteasome.GABAA receptor trafficking-mediated plasticity of inhibitory synapses.Signature changes in ubiquilin expression in the R6/2 mouse model of Huntington's disease.The F-box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE).Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse developmentIdentification and proteomic analysis of distinct UBE3A/E6AP protein complexes.The ubiquitin-like protein Plic-1 enhances the membrane insertion of GABAA receptors by increasing their stability within the endoplasmic reticulum.Studies of the role of ubiquitination in the interaction of ubiquilin with the loop and carboxyl terminal regions of presenilin-2Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome.The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine DiseaseUBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.Role of GABAA R trafficking in the plasticity of inhibitory synapses.The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.TaUBA, a UBA domain-containing protein in wheat (Triticum aestivum L.), is a negative regulator of salt and drought stress response in transgenic Arabidopsis.Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation.Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity.Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors.The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit.Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.Network analysis of UBE3A/E6AP-associated proteins provides connections to several distinct cellular processes.Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death.
P2860
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P2860
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@ast
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@en
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@nl
type
label
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@ast
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@en
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@nl
prefLabel
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@ast
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@en
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@nl
P2093
P2860
P356
P1476
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome
@en
P2093
Maurits F Kleijnen
Peter M Howley
Rodolfo M Alarcon
P2860
P304
P356
10.1091/MBC.E02-11-0766
P407
P577
2003-09-01T00:00:00Z