Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
about
Ubiquilin-1 is a molecular chaperone for the amyloid precursor proteinUbiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradationThe life cycle of the 26S proteasome: from birth, through regulation and function, and onto its deathEffects of overexpression of huntingtin proteins on mitochondrial integrity.Reduced body weight gain in ubiquilin-1 transgenic mice is associated with increased expression of energy-sensing proteinsProtein aggregation and degradation mechanisms in neurodegenerative diseasesAssociation of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.Signature changes in ubiquilin expression in the R6/2 mouse model of Huntington's disease.Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtinUbiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice.Current understanding on the pathogenesis of polyglutamine diseases.Aggrephagy: selective disposal of protein aggregates by macroautophagy.Targeting ubiquilin-1 in Alzheimer's disease.Overexpression of Ubiquilin-1 Alleviates Alzheimer's Disease-Caused Cognitive and Motor Deficits and Reduces Amyloid-β Accumulation in Mice.Enhanced Proteostasis in Post-ischemic Stroke Mouse Brains by Ubiquilin-1 Promotes Functional Recovery.The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.Modeling pathogenesis of Huntington's disease with inducible neuroprogenitor cells.Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit.
P2860
Q24634983-D5E513EF-753C-4D13-903B-8D7F96353105Q24653719-ABC6ABE4-2CA4-4BA4-B104-818A9D9E0627Q26738549-10C53FE6-2B83-4386-8FC3-7FCE1EEA8C7DQ30489322-EEF42061-65A9-4DC3-9CF4-35C8E2573F54Q33612372-05146BB8-DDF9-4980-ABBC-95A080D935B3Q34334363-D3518924-DBA1-46F5-84FC-919284BE2739Q34575601-679A15B1-80C4-462C-90F4-222F82267850Q35122320-3548F2FB-43D1-4E2F-A708-19F8638289AFQ35735022-28E3DDDA-C733-4C4A-8A52-3A10561F679AQ36272653-E0662D42-E3B6-49EB-A0EF-CE7E8BBC6E40Q36464731-B1F5FDF2-C54A-4F5E-AC5A-C42D33D84212Q37052727-7F5E2365-A71D-490D-9B7B-EC53C07FD63DQ37521285-948900A6-789C-4EB8-8BBE-67CFF9F2137FQ37555526-9340D520-E43A-4495-859A-B001FD13160FQ37636269-B675366A-478A-4482-A44F-580398478343Q37760791-174999A3-C974-4F77-A995-5CA36958A07AQ38003982-D6B5160E-1715-441B-8529-5A092713F632Q38100204-A905105C-5621-4A8D-A32E-39EC2148299CQ38734119-F13A318C-8BCF-49C8-82DA-8E332E4D6CDAQ39121172-48D07E3B-4831-4D45-9E1B-43324EFE59D0Q39213276-7B812126-A417-4A3C-B4C6-2CEC7F1292EEQ39567922-9BB2B881-6F4F-414A-9F8C-314A994CE7F6Q40355188-E9B95597-6068-4DF7-8DBB-9D6E9A424C06Q41953002-877EDA6F-D8E1-42B9-ADE7-4AD67D19E950Q42382149-386CD8AE-3FDB-4AFD-AF72-3D7B0FD3AA33Q47071242-9D843D9B-B17C-4FC5-9EAF-208F7C8EBCE0
P2860
Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
@en
Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
@nl
type
label
Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
@en
Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
@nl
prefLabel
Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
@en
Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
@nl
P2860
P1476
Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.
@en
P2093
Hongmin Wang
Mervyn J Monteiro
P2860
P304
P356
10.1016/J.BBRC.2007.06.097
P407
P577
2007-06-25T00:00:00Z