Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes - Test2 - elhamkhani - TriplyDB

Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes

Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes

http://www.wikidata.org/entity/Q24670122

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The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13 MeCP2, a key contributor to neurological disease, activates and represses transcription A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism Epigenetic principles and mechanisms underlying nervous system functions in health and disease Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in Disease MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling MECP2 disorders: from the clinic to mice and back DNA modifications: function and applications in normal and disease States Astrocytes conspire with neurons during progression of neurological disease Role of mecp2 in experience-dependent epigenetic programming Genetic modifiers of MeCP2 function in Drosophila.Immunologic and neurodevelopmental susceptibilities of autism Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin Epigenetics in the nervous system A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo Noncoding origins of anthropoid traits and a new null model of transposon functionalization MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212.IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPARγ gene in male and female rat lungs during alveolarization Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells Unexpected cellular players in Rett syndrome pathology Female Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies.Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.NET silencing by let-7i in postural tachycardia syndrome.MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy Gender influences monoallelic expression of ATP10A in human brain CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression.The Crucial Role of DNA Methylation and MeCP2 in Neuronal Function Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

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Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes

http://www.wikidata.org/entity/Q24670122

description

2007 nî lūn-bûn

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2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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name

Integrated epigenomic analyses ...... interaction with active genes

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Integrated epigenomic analyses ...... interaction with active genes

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Integrated epigenomic analyses ...... interaction with active genes

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type

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Integrated epigenomic analyses ...... interaction with active genes

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Integrated epigenomic analyses ...... interaction with active genes

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Integrated epigenomic analyses ...... interaction with active genes

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Integrated epigenomic analyses ...... interaction with active genes

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Integrated epigenomic analyses ...... interaction with active genes

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Integrated epigenomic analyses ...... interaction with active genes

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PNAS.0707442104

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Proceedings of the National Academy of Sciences of the United States of America

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Integrated epigenomic analyses ...... interaction with active genes

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Amber Hogart

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Dag H Yasui

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Karen N Thatcher

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Mark C Bieda

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Raman P Nagarajan

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Roxanne O Vallero

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Sailaja Peddada

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P2860

Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3.

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders

Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome

Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations

Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

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19416-21

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10.1073/PNAS.0707442104

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49

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104

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Janine M. LaSalle

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5804620

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