Female Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies.
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Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null miceMECP2 disorders: from the clinic to mice and backBehavioral and Neuroanatomical Phenotypes in Mouse Models of AutismRett syndrome: disruption of epigenetic control of postnatal neurological functionsTranslational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female ratsSensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.MECP2 regulates cortical plasticity underlying a learned behaviour in adult female miceLoss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome.Loss of MeCP2 in Parvalbumin-and Somatostatin-Expressing Neurons in Mice Leads to Distinct Rett Syndrome-like PhenotypesManipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disordersRestoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome.A protocol for evaluation of Rett Syndrome symptom improvement by metabolic modulators in Mecp2-mutant mice.Mild expression differences of MECP2 influencing aggressive social behavior.Preclinical research in Rett syndrome: setting the foundation for translational success.Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists.Respiratory phenotypes are distinctly affected in mice with common Rett syndrome mutations MeCP2 T158A and R168X.Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndromeTreatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgeneLong-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndromeGenotype-specific effects of Mecp2 loss-of-function on morphology of Layer V pyramidal neurons in heterozygous female Rett syndrome model mice.Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlasDeficient Purposeful Use of Forepaws in Female Mice Modelling Rett Syndrome.MeCP2 Related Studies Benefit from the Use of CD1 as Genetic Background.MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity.Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome.Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome miceGenome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injuryRescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation.Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome.Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice.Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null miceJointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome.Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures.Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α.CREB Signaling Is Involved in Rett Syndrome PathogenesisLessons learned from studying syndromic autism spectrum disorders.
P2860
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P2860
Female Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies.
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Female Mecp2(+/-) mice display ...... work for pre-clinical studies.
@ast
Female Mecp2(+/-) mice display ...... work for pre-clinical studies.
@en
type
label
Female Mecp2(+/-) mice display ...... work for pre-clinical studies.
@ast
Female Mecp2(+/-) mice display ...... work for pre-clinical studies.
@en
prefLabel
Female Mecp2(+/-) mice display ...... work for pre-clinical studies.
@ast
Female Mecp2(+/-) mice display ...... work for pre-clinical studies.
@en
P2860
P50
P356
P1476
Female Mecp2(+/-) mice display ...... work for pre-clinical studies.
@en
P2093
Christopher M McGraw
Yaling Sun
P2860
P304
P356
10.1093/HMG/DDS406
P577
2012-10-01T00:00:00Z