Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex
about
miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifsSMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decayLocalization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoanAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decayInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysUpf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayDis3-like 1: a novel exoribonuclease associated with the human exosomeUnusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosomeMechanistic and Structural Studies of Protein-Only RNase P Compared to Ribonucleoproteins Reveal the Two Faces of the Same Enzymatic ActivityNonsense-mediated mRNA decay: novel mechanistic insights and biological impactCrystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operonStructure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1The Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITSStructural and functional analysis of the archaeal endonuclease Nob1.Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNaseStructural and functional analysis of Utp23, a yeast ribosome synthesis factor with degenerate PIN domainPhospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexesSaccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities.Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain.Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryProtein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomeraseCharacterization of Novel Ribosome-Associated Endoribonuclease SLFN14 from Rabbit ReticulocytesInterleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNAAnalysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active siteHow and where are nonsense mRNAs degraded in mammalian cells?Mutations in AtPS1 (Arabidopsis thaliana parallel spindle 1) lead to the production of diploid pollen grainsThe TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasisEndoribonucleases--enzymes gaining spotlight in mRNA metabolism.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansThe RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domainMultifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components.Interdependent nucleocytoplasmic trafficking and interactions of Dis3 with Rrp6, the core exosome and importin-alpha3Evolution of parallel spindles like genes in plants and highlight of unique domain architecture#Comprehensive classification of the PIN domain-like superfamilyDiverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.
P2860
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P2860
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex
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2006 nî lūn-bûn
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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
@zh-mo
2006年論文
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2006年论文
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Structures of the PIN domains ...... the mRNA surveillance complex
@ast
Structures of the PIN domains ...... the mRNA surveillance complex
@en
Structures of the PIN domains ...... the mRNA surveillance complex
@nl
type
label
Structures of the PIN domains ...... the mRNA surveillance complex
@ast
Structures of the PIN domains ...... the mRNA surveillance complex
@en
Structures of the PIN domains ...... the mRNA surveillance complex
@nl
prefLabel
Structures of the PIN domains ...... the mRNA surveillance complex
@ast
Structures of the PIN domains ...... the mRNA surveillance complex
@en
Structures of the PIN domains ...... the mRNA surveillance complex
@nl
P2860
P50
P3181
P356
P1433
P1476
Structures of the PIN domains ...... the mRNA surveillance complex
@en
P2093
Filip Glavan
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601377
P407
P577
2006-11-01T00:00:00Z