Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor - Test2 - elhamkhani - TriplyDB

Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

http://www.wikidata.org/entity/Q24672246

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Orexin receptors: pharmacology and therapeutic opportunities Physiology of the orexinergic/hypocretinergic system: a revisit in 2012 Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls Multiple roles for orexin/hypocretin in addiction Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action.Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.Discovery Of An Orexin Receptor Positive Potentiator A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress.The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stress Chemistry and biology of orexin signaling.The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship.Neuropeptides controlling energy balance: orexins and neuromedins.Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors.The hypocretin/orexin receptor: therapeutic prospective in sleep disorders.Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits Microarray-assisted fine mapping of quantitative trait loci on chromosome 15 for susceptibility to seizure-induced cell death in mice.Discovery and development of orexin receptor antagonists as therapeutics for insomnia.Drugs for insomnia.Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status.Orexin/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA?The hypocretin/orexin system: an increasingly important role in neuropsychiatry.The role of orexin in motivated behaviours.Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A.Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.CSF levels of hypocretin-1 (orexin-A) peak during early infancy in humans.Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function.Orexin receptor subtype activation and locomotor behaviour in the rat.Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.Orexinergic innervation of the extended amygdala and basal ganglia in the rat.The Human Orexin/Hypocretin Receptor Crystal Structures.Orexin-A increases the firing activity of hippocampal CA1 neurons through orexin-1 receptors.The Molecular Basis of Insomnia: Implication for Therapeutic Approaches.

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Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

http://www.wikidata.org/entity/Q24672246

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Characterisation of the bindin ...... to the human orexin-1 receptor

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Characterisation of the bindin ...... to the human orexin-1 receptor

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Characterisation of the bindin ...... to the human orexin-1 receptor

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Characterisation of the bindin ...... to the human orexin-1 receptor

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Characterisation of the bindin ...... to the human orexin-1 receptor

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Characterisation of the bindin ...... to the human orexin-1 receptor

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Characterisation of the bindin ...... to the human orexin-1 receptor

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Characterisation of the bindin ...... to the human orexin-1 receptor

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British Journal of Pharmacology

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Characterisation of the bindin ...... to the human orexin-1 receptor

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Christopher J Langmead

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Claire Scott

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Hugh J Herdon

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Jeffrey C Jerman

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Rod A Porter

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Stephen J Brough

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P2860

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

SB-334867-A: the first selective orexin-1 receptor antagonist

Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats.

Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin.

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.

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340-6

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10.1038/SJ.BJP.0705610

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2

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141

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2004-01-01T00:00:00Z

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8946105

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14691055

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1574197

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