Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation - Test2 - elhamkhani - TriplyDB

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

http://www.wikidata.org/entity/Q24673794

about

Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains Nucleolus: the fascinating nuclear body Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis In vitro selection of mutant HDM2 resistant to Nutlin inhibition Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation Molecular characterization of the Ran-binding zinc finger domain of Nup153 Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia Role of ribosomal protein mutations in tumor development (Review)p53 as a Regulator of Lipid Metabolism in Cancer An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction Functional analysis of a novel ENU-induced PHD finger 11 (Phf11) mouse mutant Therapeutic considerations for Mdm2: not just a one trick pony CanProVar: a human cancer proteome variation database.Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation CAERUS: predicting CAncER oUtcomeS using relationship between protein structural information, protein networks, gene expression data, and mutation data.Diamond-Blackfan anemia: diagnosis, treatment, and molecular pathogenesis.The in vivo role of the RP-Mdm2-p53 pathway in signaling oncogenic stress induced by pRb inactivation and Ras overexpression.The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26.Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory.Deconstructing nucleotide binding activity of the Mdm2 RING domain.MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications Ribosomal proteins: functions beyond the ribosome Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress.Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine.Signaling to p53: ribosomal proteins find their way.Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation The RP-Mdm2-p53 pathway and tumorigenesis Gene and protein expressions induced by 17beta-estradiol and parathion in cultured breast epithelial cells.Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin.The Regulation of Multiple p53 Stress Responses is Mediated through MDM2 Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor.Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation.Oncogenic c-Myc-induced lymphomagenesis is inhibited non-redundantly by the p19Arf-Mdm2-p53 and RP-Mdm2-p53 pathways Characterization of cancer-associated missense mutations in MDM2.

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P2860

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

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2007 nî lūn-bûn

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2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2007 թվականի փետրվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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Cancer-associated mutations in ...... e MDM2-induced p53 degradation

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Cancer-associated mutations in ...... e MDM2-induced p53 degradation

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Gabrielle White Wolf

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Yanping Zhang

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P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Mdm2 promotes the rapid degradation of p53

Interaction between the retinoblastoma protein and the oncoprotein MDM2

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Repression of p53-mediated transcription by MDM2: a dual mechanism

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.

Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

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2501733

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10.1128/MCB.01307-06

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3

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27

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17116689

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1800693

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