Mechanism of thioamide drug action against tuberculosis and leprosy
about
Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosisA virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhAInhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamidesTriclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-ResistantMycobacterium tuberculosisHigh-resolution structures ofThermus thermophilusenoyl-acyl carrier protein reductase in the apo form, in complex with NAD+and in complex with NAD+and triclosanAntibacterial targets in fatty acid biosynthesisThiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteriaDrug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosisSynthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analoguesMycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosisWhole genome sequencing reveals complex evolution patterns of multidrug-resistant Mycobacterium tuberculosis Beijing strains in patientsThe role of selection in shaping diversity of natural M. tuberculosis populationsThe thioamides methimazole and thiourea inhibit growth of M. avium Subspecies paratuberculosis in cultureAutomatic design of decision-tree induction algorithms tailored to flexible-receptor docking data.Context-based preprocessing of molecular docking dataA synthetic mammalian gene circuit reveals antituberculosis compounds.The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South AfricaMining flexible-receptor docking experiments to select promising protein receptor snapshots.Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.FReDoWS: a method to automate molecular docking simulations with explicit receptor flexibility and snapshots selection.Effect of the explicit flexibility of the InhA enzyme from Mycobacterium tuberculosis in molecular docking simulations.Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases.Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone.Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosisComparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivationA fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boostersNew approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Heme and I.Revisiting the susceptibility testing of Mycobacterium tuberculosis to ethionamide in solid culture medium.Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomesNew drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections.Treatment of tuberculosis in children.Mycobacterium tuberculosis: drug resistance and future perspectives.Synthetic biology in the analysis and engineering of signaling processes.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Microbial transformation of azaarenes and potential uses in pharmaceutical synthesis.Anaerobic bacteria as producers of antibiotics.Recycling and refurbishing old antitubercular drugs: the encouraging case of inhibitors of mycolic acid biosynthesis.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Safety and tolerability profile of second-line anti-tuberculosis medications.
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P2860
Mechanism of thioamide drug action against tuberculosis and leprosy
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Mechanism of thioamide drug action against tuberculosis and leprosy
@ast
Mechanism of thioamide drug action against tuberculosis and leprosy
@en
Mechanism of thioamide drug action against tuberculosis and leprosy
@nl
type
label
Mechanism of thioamide drug action against tuberculosis and leprosy
@ast
Mechanism of thioamide drug action against tuberculosis and leprosy
@en
Mechanism of thioamide drug action against tuberculosis and leprosy
@nl
prefLabel
Mechanism of thioamide drug action against tuberculosis and leprosy
@ast
Mechanism of thioamide drug action against tuberculosis and leprosy
@en
Mechanism of thioamide drug action against tuberculosis and leprosy
@nl
P2860
P50
P356
P1476
Mechanism of thioamide drug action against tuberculosis and leprosy
@en
P2093
James C Sacchettini
Robert Langley
P2860
P356
10.1084/JEM.20062100
P407
P577
2007-01-16T00:00:00Z