The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK - Test2 - elhamkhani - TriplyDB

The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK

The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK

http://www.wikidata.org/entity/Q24676906

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CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement Genome stability is ensured by temporal control of kinetochore-microtubule dynamics Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres MCAK associates with the tips of polymerizing microtubules The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.Functional importance of the anaphase-promoting complex-Cdh1-mediated degradation of TMAP/CKAP2 in regulation of spindle function and cytokinesis.NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles.A second tubulin binding site on the kinesin-13 motor head domain is important during mitosis TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux.Structure of the Kinesin13-Microtubule Ring Complex The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly.Kif2a depletion generates chromosome segregation and pole coalescence defects in animal caps and inhibits gastrulation of the Xenopus embryo.ICIS and Aurora B coregulate the microtubule depolymerase Kif2a Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function.Deciphering protein function during mitosis in PtK cells using RNAi.Prophase microtubule arrays undergo flux-like behavior in mammalian cells Kinesin-13s form rings around microtubules Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle.Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.Molecular control of kinetochore-microtubule dynamics and chromosome oscillations Kif18B interacts with EB1 and controls astral microtubule length during mitosis.The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.Kinetochore-microtubule stability governs the metaphase requirement for Eg5.Oxidative stress decreases microtubule growth and stability in ventricular myocytes Phosphorylation of SKAP by GSK3β ensures chromosome segregation by a temporal inhibition of Kif2b activity.Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.Targeting of integrin beta1 and kinesin 2alpha by microRNA 183 How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays.Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer.Ras transformation uncouples the kinesin-coordinated cellular nutrient response Kinesins at a glance

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The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK

http://www.wikidata.org/entity/Q24676906

description

2004 nî lūn-bûn

@nan

2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2004年の論文

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2004年論文

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2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

@ast

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

@en

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

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type

label

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

@ast

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

@en

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

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prefLabel

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

@ast

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

@en

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

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P1433

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P3181

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P1433

Journal of Cell Biology

P1476

The KinI kinesin Kif2a is requ ...... ctional relationship with MCAK

@en

P2093

Duane A Compton

http://www.w3.org/2001/XMLSchema#string

Neil J Ganem

http://www.w3.org/2001/XMLSchema#string

P2860

TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly

Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique

Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein

Mitotic centromere-associated kinesin is important for anaphase chromosome segregation

The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles

Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles.

A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Novel roles for saccharomyces cerevisiae mitotic spindle motors.

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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473-8

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scholarly article

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3286906

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10.1083/JCB.200404012

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P433

4

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166

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P577

2004-08-16T00:00:00Z

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P5875

8408016

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P698

15302853

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2172212

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