Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations - Test2 - elhamkhani - TriplyDB

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

http://www.wikidata.org/entity/Q24678876

about

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1 The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1 Reconstructing immune phylogeny: new perspectives Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.AID targeting is dependent on RNA polymerase II pausing.Retroviral restriction by APOBEC proteins Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice Simultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathways Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells Analysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversity AID and Apobec3G haphazard deamination and mutational diversity Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase Mice deficient in APOBEC2 and APOBEC3.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast Affinity maturation of anti-TNF-alpha scFv with somatic hypermutation in non-B cells.Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase.Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5 MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.Targeting of somatic hypermutation.Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex Targeting of AID-mediated sequence diversification to immunoglobulin genes Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Genomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development.DNA-cytosine deaminases: from antibody maturation to antiviral defense.The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias

P2860

Q24307678-A3C8427C-7AB0-48A7-B70A-9B842183F83F Q24337929-A036D46F-FBBA-4406-9C67-2F76AACD4EA5 Q24562606-23389045-D8C5-47ED-8FDD-061E3BB57349 Q24611953-B27A920C-840C-4F48-A22D-67F2D8DE0949 Q24814190-2ABA9F12-B174-46CC-A1E1-FDFAA792CD47 Q27337984-807E6537-3B81-4241-A4AC-2BEEEC5987AA Q27677864-3DDCBB29-E7EF-40D2-B81A-7566B2C4678D Q27692655-E648186F-0708-4522-93A6-4B0C30683E70 Q28290721-E2F68281-A360-4226-8477-441E038FDB23 Q28508643-60DE1062-D3BA-4956-AB60-42316F742FD7 Q28513971-2B1398EF-E7C1-4526-98BB-9D5DB9712B01 Q28536559-88C21D22-BE2B-4C5D-808C-911013C292B4 Q28589828-5B16A88B-EEC1-4077-8BDD-5159B5E2638D Q28590572-FD4BC4CA-68FA-4531-A508-25AC55C5F850 Q30502490-BF666EA6-32A1-4DC6-B083-0CBCC612641C Q30537745-A62C146F-0C56-4D07-A30A-698ACAC0B832 Q33299999-D28A6494-18B8-41CE-ADE1-4BB1DA5B0698 Q33328760-4F4D108C-538D-4351-B189-4105A7EAAED6 Q33341846-FBB839B5-2093-45B9-AB69-7C6DBBFBABFA Q33379345-CFFD8123-690C-4611-837C-47F7778D2E3E Q33690522-08A46D4C-8F5D-4D97-86C5-020EF8088C6B Q33819022-48C6803C-C270-41A6-8B0B-389133DC9556 Q33837311-B29B1A80-F6FC-4AB1-8E6B-93C8341FB770 Q33924977-40214752-7FAB-4593-94F4-F17EFAB083D5 Q34115234-E51A0751-7C78-45CD-8B4C-3B07DDC59F8D Q34162337-5A24F370-1A24-44C5-855F-6D98A5DB220B Q34182253-45710EBA-CE56-48C1-A6A6-66780C5C763E Q34216459-737DF8EF-01FD-4993-A1C1-947761D1E930 Q34310757-B213DA7A-8969-4E8C-A642-0966392CDA2D Q34310763-D7957318-198D-4D67-88AE-CBEA2CDA64D4 Q34357060-4D3B8007-6F60-48EA-9F2E-440C47306C6E Q34394298-048E5E07-360F-4016-A0D4-7E091582313C Q34551108-8F93FB7F-8540-445C-A729-A36683FF5D80 Q34626621-373BE53F-EF77-468B-BF97-E24B19216833 Q34777596-95B08E85-8D73-47F2-8616-3E8411C7BFB0 Q35119826-F8E07226-60F0-4287-9DA9-B208F5BA0530 Q35280881-DE45EB7D-62C6-48E6-8432-5F00AB6F84FF Q35617308-91AC21FF-57F1-4B9C-95DC-94612022314B Q35734132-176A0D32-400D-4823-8215-46AFF53941FE Q35792957-ABDFE155-49FC-47C0-92C1-0E7CE1A73ABF

P2860

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

http://www.wikidata.org/entity/Q24678876

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Human activation-induced cytid ...... and-biased C to U deaminations

@ast

Human activation-induced cytid ...... and-biased C to U deaminations

@en

Human activation-induced cytid ...... and-biased C to U deaminations

@nl

type

label

Human activation-induced cytid ...... and-biased C to U deaminations

@ast

Human activation-induced cytid ...... and-biased C to U deaminations

@en

Human activation-induced cytid ...... and-biased C to U deaminations

@nl

prefLabel

Human activation-induced cytid ...... and-biased C to U deaminations

@ast

Human activation-induced cytid ...... and-biased C to U deaminations

@en

Human activation-induced cytid ...... and-biased C to U deaminations

@nl

P1433

Q24678876-CEDDEA49-A2E3-4685-AFA0-4DF61739AD41

P1476

Q24678876-27CF368E-3A12-4F5E-A7BB-71C4F34B5294

P2093

Q24678876-43E0B405-451E-4262-A44E-E0E0F9A54D74

Q24678876-6BB45B60-B199-4126-9CAB-D114368F816A

Q24678876-C29B7FE3-0CA1-472E-97A3-2AC64D9D2B03

Q24678876-CC92F85D-2DF7-45E3-A9B4-5279B07DAC2E

Q24678876-DDDB8AC0-CA5D-4DDF-B18F-89DB7AD4C97F

P2860

Q24678876-0D1B5C57-A0D6-419A-AE88-386BD0717581

Q24678876-1647A4BB-216E-47CF-B81B-02EA890D3584

Q24678876-16E32627-CEC7-4D71-8EEB-6523C1E4ECAE

Q24678876-16FAF238-D87E-4B5C-8ED4-7775B871895A

Q24678876-192424AB-30A0-40E3-A327-30746832976E

Q24678876-20D1F766-6C90-4076-A919-1D94A4946A84

Q24678876-23546933-262E-4E5B-8A72-43E880E12031

Q24678876-2BC2851C-DF1B-46AE-8109-5D9944005339

Q24678876-340CDD46-D9B9-4D9E-BFEC-D4B1DA7C6682

Q24678876-38F76A47-D478-4D8D-8A3F-2B45CF219264

P304

Q24678876-A090C309-3AE2-4E60-BBFE-17438EE402D8

P31

Q24678876-817B8035-1E10-478E-B352-8F95AF8C2516

P356

Q24678876-44B8A797-7969-425F-BD83-AFF3172702BD

P407

Q24678876-9C52DF36-51ED-4841-AB30-5B33E12BC47A

P433

Q24678876-CAFB9B85-1D72-482D-9F34-DFC131F53770

P478

Q24678876-32C8EFD6-0CA3-40FE-A583-0804DAD5A225

P577

Q24678876-B94264FC-F457-42C5-9457-5936F27411A5

P5875

Q24678876-3007FE4F-BA05-4CEF-9179-BE80E5612D0C

P698

Q24678876-A80EF2ED-327C-455D-83C5-2935DB5C9501

P921

Q24678876-E93DB279-2EA4-4997-B3F1-5FAC1588C843

P932

Q24678876-589E87FD-8901-4124-B2A5-9157066489A0

P356

P1433

Nucleic Acids Research

P1476

Human activation-induced cytid ...... and-biased C to U deaminations

@en

P2093

Anjum Sohail

http://www.w3.org/2001/XMLSchema#string

Asad Ullah

http://www.w3.org/2001/XMLSchema#string

Ashok S Bhagwat

http://www.w3.org/2001/XMLSchema#string

Joanna Klapacz

http://www.w3.org/2001/XMLSchema#string

Mala Samaranayake

http://www.w3.org/2001/XMLSchema#string

P2860

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1)

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

Transcription-induced cytosine-to-thymine mutations are not dependent on sequence context of the target cytosine.

Determining mutation rates in bacterial populations

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.

Transcription-dependent increase in multiple classes of base substitution mutations in Escherichia coli

P304

2990-4

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/NAR/GKG464

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

31

http://www.w3.org/2001/XMLSchema#string

P577

2003-06-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

277510085

http://www.w3.org/2001/XMLSchema#string

P698

12799424

http://www.w3.org/2001/XMLSchema#string

P921

P932

162340

http://www.w3.org/2001/XMLSchema#string