Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase - Test2 - elhamkhani - TriplyDB

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

http://www.wikidata.org/entity/Q24683335

about

Transcription-coupled mutagenesis by the DNA deaminase AID Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1 Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1 Alternative induction of meiotic recombination from single-base lesions of DNA deaminases Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review)The APOBEC3 family of retroelement restriction factors Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination Mechanism and function of oxidative reversal of DNA and RNA methylation Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody AID/APOBEC deaminases and cancer RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome TGF-β triggers HBV cccDNA degradation through AID-dependent deamination DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming Retroviral restriction by APOBEC proteins Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice Processive DNA demethylation via DNA deaminase-induced lesion resolution Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination Update on the hyper immunoglobulin M syndromes 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.Temporal regulation of Ig gene diversification revealed by single-cell imaging.Analysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversity AID and Apobec3G haphazard deamination and mutational diversity Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.Chromatin structure regulates gene conversion.

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

http://www.wikidata.org/entity/Q24683335

description

2003 nî lūn-bûn

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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2003 թվականի ապրիլին հրատարակված գիտական հոդված

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2003年の論文

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Proceedings of the National Academy of Sciences of the United States of America

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Matthew D Scharff

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Myron F Goodman

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Phuong Pham

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Ronda Bransteitter

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P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Somatic hypermutation of the AID transgene in B and non-B cells

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

Error-prone repair DNA polymerases in prokaryotes and eukaryotes.

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

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12651944

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