Transcription-targeted DNA deamination by the AID antibody diversification enzyme
about
Out of balance: R-loops in human diseaseTranscription-coupled mutagenesis by the DNA deaminase AIDHydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brainActivation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesMutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificitiesRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationEssential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesAlternative induction of meiotic recombination from single-base lesions of DNA deaminasesHuman activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminationsExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesMutations, kataegis and translocations in B cells: understanding AID promiscuous activityRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.AID targeting is dependent on RNA polymerase II pausing.The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.AID/APOBEC deaminases and cancerRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeTGF-β triggers HBV cccDNA degradation through AID-dependent deaminationDNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retrovirusesAID targeting: old mysteries and new challengesAPOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA ReplicationActivation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogrammingRetroviral restriction by APOBEC proteinsDeletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsThe splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNAAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant micePTIP promotes chromatin changes critical for immunoglobulin class switch recombinationMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cellsA PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complexThe transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells53BP1 is required for class switch recombination.53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.Molecular characterization of in vivo adjuvant activity in ferrets vaccinated against influenza virusTemporal regulation of Ig gene diversification revealed by single-cell imaging.Analysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversityAID and Apobec3G haphazard deamination and mutational diversity
P2860
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P2860
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@ast
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@en
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@nl
type
label
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@ast
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@en
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@nl
prefLabel
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@ast
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@en
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@nl
P2093
P3181
P356
P1433
P1476
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
@en
P2093
Chan Khuong
Frederick W Alt
Jayanta Chaudhuri
Katrin Chua
P2888
P304
P3181
P356
10.1038/NATURE01574
P407
P50
P577
2003-04-09T00:00:00Z
P6179
1042422670