Transmodulation between phospholipase D and c-Src enhances cell proliferation - Test2 - elhamkhani - TriplyDB

Transmodulation between phospholipase D and c-Src enhances cell proliferation

Transmodulation between phospholipase D and c-Src enhances cell proliferation

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The elucidation of novel SH2 binding sites on PLD2 Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development.The C terminus of c-Src inhibits breast tumor cell growth by a kinase-independent mechanism.Wounding sheets of epithelial cells activates the epidermal growth factor receptor through distinct short- and long-range mechanisms.Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT)-3 by thyroid oncogenic kinase RET/PTC Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells Requirement of phospholipase D1 activity in H-RasV12-induced transformation A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation.Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts.PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic retinal neovascularization.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer Nuclear localization of phospholipase D1 mediates the activation of nuclear protein kinase C(alpha) and extracellular signal-regulated kinase signaling pathways.The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2.The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).Phospholipase D: enzymology, functionality, and chemical modulation Targeting mTOR-mediated survival signals in anticancer therapeutic strategies.Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes.The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus.Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner.Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.Phospholipase D1 has a pivotal role in interleukin-1β-driven chronic autoimmune arthritis through regulation of NF-κB, hypoxia-inducible factor 1α, and FoxO3a Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells.PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation.Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis.Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease.Genes and molecular pathways related to radioresistance of oral squamous cell carcinoma cells.Cleavage of phospholipase D1 by caspase promotes apoptosis via modulation of the p53-dependent cell death pathway.Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells.Alternative phospholipase D/mTOR survival signal in human breast cancer cells.Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells.Regulation of phospholipase D2 activity by protein kinase C alpha.Differential expression of phospholipase D isozymes in the hippocampus following kainic acid-induced seizures.

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

http://www.wikidata.org/entity/Q24682831

description

2003 nî lūn-bûn

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2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2003 թվականի մայիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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MCB.23.9.3103-3115.2003

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Molecular and Cellular Biology

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Transmodulation between phospholipase D and c-Src enhances cell proliferation

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Bong-Hyun Ahn

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Do Sik Min

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Jong-Soo Chang

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Kyeong Sook Choi

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Myung-Suk Kim

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Shi Yeon Kim

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Taeg Kyu Kwon

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Yang-Hyeok Jo

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Young Han Lee

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P2860

c-Src-dependent Activation of the Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase Pathway by Arsenic

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

The Phox homology (PX) domain, a new player in phosphoinositide signalling

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

Differential tyrosine phosphorylation of phospholipase D isozymes by hydrogen peroxide and the epidermal growth factor in A431 epidermoid carcinoma cells

Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction

alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells

PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation

Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha

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