Crystal structures of c-Src reveal features of its autoinhibitory mechanism
about
Structural evolution of the protein kinase-like superfamilyA systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM databaseSubstrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptorCbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motilityCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonTrafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domainPhosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migrationSubdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylationXB130, a novel adaptor protein for signal transductionGPRC5B activates obesity-associated inflammatory signaling in adipocytesProline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activationStructural basis for the recognition of c-Src by its inactivator CskThe tyrosine kinase Csk dimerizes through Its SH3 domainAllosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1Deciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction siteFgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophilsRetroviral oncogenes: a historical primerHighly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocyclesSteroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferationCross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasisTransmodulation between phospholipase D and c-Src enhances cell proliferationErbB receptors: from oncogenes to targeted cancer therapiesEstrogen receptors in gastric cancer: Advances and perspectivesThe Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer CellsThe spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imagingBinding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: Implications for allosteric regulationCrystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanismCrystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemiaStructural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemiaModulation of the Active Complex Assembly and Turnover Rate by Protein−DNA Interactions in Cre−LoxP Recombination † , ‡Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKsStructural analysis of the catalytically inactive kinase domain of the human EGF receptor 3Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound stateStructural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinasesCrystal structure of the ALK (anaplastic lymphoma kinase) catalytic domainCrystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation MechanismCrystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide ClassATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunitStructural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix
P2860
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P2860
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@ast
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@en
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@nl
type
label
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@ast
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@en
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@nl
prefLabel
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@ast
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@en
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@nl
P2093
P3181
P1433
P1476
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
@en
P2093
P304
P3181
P356
10.1016/S1097-2765(00)80356-1
P50
P577
1999-05-01T00:00:00Z