DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis - Test2 - elhamkhani - TriplyDB

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

http://www.wikidata.org/entity/Q24683000

about

ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2 Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex GEF what? Dock180 and related proteins help Rac to polarize cells in new ways Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis Function and Regulation of Heterotrimeric G Proteins during Chemotaxis Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes Kinase AKT controls innate immune cell development and function Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development.Apoptotic cell recognition receptors and scavenger receptors.Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells Mechanisms and consequences of neutrophil interaction with the endothelium.Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis.Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling.Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility.Two-photon microscopy analysis of leukocyte trafficking and motility.Mammalian erythroblast enucleation requires PI3K-dependent cell polarization The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity Homer3 regulates the establishment of neutrophil polarity The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.Essential role of Elmo1 in Dock2-dependent lymphocyte migration The signaling mechanisms underlying cell polarity and chemotaxis Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.Dedicator of cytokinesis 8 (DOCK8) deficiency Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling.The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells Big roles for small GTPases in the control of directed cell movement.

P2860

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P2860

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

http://www.wikidata.org/entity/Q24683000

description

2006 nî lūn-bûn

@nan

2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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type

label

DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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prefLabel

DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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P1433

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P2860

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P1433

Journal of Cell Biology

P1476

DOCK2 is a Rac activator that ...... y during neutrophil chemotaxis

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P2093

Ayumi Inayoshi

http://www.w3.org/2001/XMLSchema#string

Fumiyuki Sanematsu

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Ken-ichi Watanabe

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Mayuko Noda

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Ryosuke Takii

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Takehiko Sasazuki

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Yoshihiko Tanaka

http://www.w3.org/2001/XMLSchema#string

Yuya Kunisaki

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P2860

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.

DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells

P304

647-652

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scholarly article

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3219319

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P356

10.1083/JCB.200602142

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P407

P433

5

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P478

174

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P50

Akihiko Nishikimi

Yoshinori Fukui

Takehiko Sasaki

P577

2006-08-01T00:00:00Z

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P5875

6845966

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16943182

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P932

2064308

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