Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling - Test2 - elhamkhani - TriplyDB

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

http://www.wikidata.org/entity/Q24685123

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Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling Wnt/beta-catenin signaling and small molecule inhibitors Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis Key role for ubiquitin protein modification in TGFβ signal transduction DEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticity The GSK-3 family as therapeutic target for myocardial diseases Emerging roles of Axin in cerebral cortical development AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction: regulation of the AKT downstream pathway Regulation of protein stability by GSK3 mediated phosphorylation.GSK-3: Functional Insights from Cell Biology and Animal Models.DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition Functional Wnt signaling is increased in idiopathic pulmonary fibrosis Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation.Pin1 promotes transforming growth factor-beta-induced migration and invasion.Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3 Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases Smad signaling in skeletal development and regeneration.Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1.FGF10: Type III Epithelial Mesenchymal Transition and Invasion in Breast Cancer Cell Lines Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts.TGF-β and restenosis revisited: a Smad link.What Are the bona fide GSK3 Substrates?Role of STRAP in regulating GSK3β function and Notch3 stabilization.Effects of THAP11 on erythroid differentiation and megakaryocytic differentiation of K562 cells.A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice.Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction Single Chain Antibodies as Tools to Study transforming growth factor-β-Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens.A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice.

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Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

http://www.wikidata.org/entity/Q24685123

description

2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

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name

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@ast

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@en

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@nl

type

label

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@ast

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@en

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@nl

prefLabel

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@ast

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@en

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@nl

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Genes & Development

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Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

@en

P2093

Alejandro Ramirez

http://www.w3.org/2001/XMLSchema#string

David S Waddell

http://www.w3.org/2001/XMLSchema#string

Xiao-Fan Wang

http://www.w3.org/2001/XMLSchema#string

Xing Guo

http://www.w3.org/2001/XMLSchema#string

Zhizhong Li

http://www.w3.org/2001/XMLSchema#string

P2860

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

TGF beta signals through a heteromeric protein kinase receptor complex

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

P304

106-120

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scholarly article

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3626779

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10.1101/GAD.1590908

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1

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22

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2008-01-01T00:00:00Z

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5677975

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18172167

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2151009

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