PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
about
MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomesAblation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cellLigand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signalingNuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathwaysNuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signalingNovel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activityTAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewalMetal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatasePPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasisCritical regulation of TGFbeta signaling by Hsp90Nodal morphogensErbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domainAxin and GSK3- control Smad3 protein stability and modulate TGF- signalingRegulation of TGF-β signal transduction by mono- and deubiquitylation of SmadsTGF-β cascade regulation by PPP1 and its interactors -impact on prostate cancer development and therapyTargeting TGF-β signaling in cancerThe proteomic landscape of triple-negative breast cancer.MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary FibrosisMolecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP)A Smad action turnover switch operated by WW domain readers of a phosphoserine codeSevere acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signalingTGFβ signalling in contextTGFbeta in CancerPulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesisActivation of protein serine/threonine phosphatase PP2Cα efficiently prevents liver fibrosisC-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylationRedox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expressionN-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cellsPpm1b negatively regulates necroptosis through dephosphorylating Rip3Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell DifferentiationA genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucomaResponse projected clustering for direct association with physiological and clinical response dataGene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data.Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.Constraint-based modeling and kinetic analysis of the Smad dependent TGF-beta signaling pathway.Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop.Transcript-specific expression profiles derived from sequence-based analysis of standard microarrays.Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development.
P2860
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P2860
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@ast
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@en
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@en-gb
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@nl
type
label
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@ast
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@en
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@en-gb
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@nl
prefLabel
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@ast
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@en
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@en-gb
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@nl
P2093
P921
P3181
P1433
P1476
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
@en
P2093
Anming Meng
Candi M Davis
F Charles Brunicardi
Jianyin Long
Jinrong Wang
Katharine H Wrighton
Xin-Hua Feng
Xueyan Duan
P304
P3181
P356
10.1016/J.CELL.2006.03.044
P407
P50
P577
2006-06-01T00:00:00Z