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α-Synuclein as an intrinsically disordered monomer--fact or artefact?Definition of a molecular pathway mediating α-synuclein neurotoxicityα-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formationNative α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2Versatile Structures of α-SynucleinDynamic structural flexibility of α-synucleinPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Biophysical characterization of α-synuclein and its controversial structurePropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.The Synaptic Function of α-SynucleinAlpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body DisordersAlpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical ApplicationAPP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functionsSpontaneously Hypertensive Rats (SHR) Are Resistant to a Reserpine-Induced Progressive Model of Parkinson's Disease: Differences in Motor Behavior, Tyrosine Hydroxylase and α-Synuclein Expressionα-Synuclein is a Novel Microtubule Dynamase.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesMechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Towards translational therapies for multiple system atrophyNonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding.Novel therapeutic approaches in multiple system atrophyPurification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.A new method for quantitative immunoblotting of endogenous α-synuclein.N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis.Molecular details of α-synuclein membrane association revealed by neutrons and photons.Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution.Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiationCysteine cathepsins are essential in lysosomal degradation of α-synuclein.Heme Stabilization of α-Synuclein Oligomers during Amyloid Fibril Formation.KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.From intrinsically disordered protein to context-dependent folding: The α-synuclein tetramer is teased out of hidingDistinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutationA Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo.A small-angle X-ray scattering study of alpha-synuclein from human red blood cellsPrinciples of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synucleinN-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes.Evidence of native α-synuclein conformers in the human brain.Amyloid β-protein oligomers and Alzheimer's disease.Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Properties of native brain α-synuclein
@ast
Properties of native brain α-synuclein
@en
Properties of native brain α-synuclein
@nl
type
label
Properties of native brain α-synuclein
@ast
Properties of native brain α-synuclein
@en
Properties of native brain α-synuclein
@nl
prefLabel
Properties of native brain α-synuclein
@ast
Properties of native brain α-synuclein
@en
Properties of native brain α-synuclein
@nl
P2860
P50
P3181
P356
P1433
P1476
Properties of native brain α-synuclein
@en
P2093
Manu Sharma
Sandro Vivona
P2860
P2888
P304
E4-6; discussion E6-7
P3181
P356
10.1038/NATURE12125
P407
P577
2013-06-13T00:00:00Z
P6179
1026388289