α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
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Definition of a molecular pathway mediating α-synuclein neurotoxicityVersatile Structures of α-SynucleinDynamic structural flexibility of α-synucleinNeuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein AggregationAlpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons DiseaseThe associations between Parkinson's disease and cancer: the plot thickensΑlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's DiseaseThe Synaptic Function of α-SynucleinAlpha-synuclein structure, functions, and interactionsSeeking a mechanism for the toxicity of oligomeric α-synucleinAlpha-synuclein spreading in Parkinson's diseaseMinimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAKChemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's DiseaseCharacterization of α-Synuclein Multimer Stoichiometry in Complex Biological Samples by ElectrophoresisTotal α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA.α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotectionAlpha-synuclein function and dysfunction on cellular membranes.Molecular details of α-synuclein membrane association revealed by neutrons and photons.Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicityParkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiationCysteine cathepsins are essential in lysosomal degradation of α-synuclein.KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein.ExPLAining early synucleinopathies.Targeting protein aggregation for the treatment of degenerative diseasesAltered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.α-Synuclein expression in the mouse cerebellum is restricted to VGluT1 excitatory terminals and is enriched in unipolar brush cells.Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein.Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain.Preparation and Characterization of Stable α-Synuclein Lipoprotein ParticlesCortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's diseaseNuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains.Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregationEnvironmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.
P2860
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P2860
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
α-Synuclein assembles into hig ...... romote SNARE complex formation
@ast
α-Synuclein assembles into hig ...... romote SNARE complex formation
@en
α-Synuclein assembles into hig ...... romote SNARE complex formation
@nl
type
label
α-Synuclein assembles into hig ...... romote SNARE complex formation
@ast
α-Synuclein assembles into hig ...... romote SNARE complex formation
@en
α-Synuclein assembles into hig ...... romote SNARE complex formation
@nl
prefLabel
α-Synuclein assembles into hig ...... romote SNARE complex formation
@ast
α-Synuclein assembles into hig ...... romote SNARE complex formation
@en
α-Synuclein assembles into hig ...... romote SNARE complex formation
@nl
P2860
P3181
P356
P1476
α-Synuclein assembles into hig ...... romote SNARE complex formation
@en
P2093
Manu Sharma
P2860
P304
P3181
P356
10.1073/PNAS.1416598111
P407
P577
2014-10-07T00:00:00Z