Small molecule tools for functional interrogation of protein tyrosine phosphatases - Test2 - elhamkhani - TriplyDB

Small molecule tools for functional interrogation of protein tyrosine phosphatases

Small molecule tools for functional interrogation of protein tyrosine phosphatases

http://www.wikidata.org/entity/Q26852276

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Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction Cellular biochemistry methods for investigating protein tyrosine phosphatases Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors.Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria Targeting the disordered C terminus of PTP1B with an allosteric inhibitor Metabolic regulation by protein tyrosine phosphatases.New hippolide derivatives with protein tyrosine phosphatase 1B inhibitory activity from the marine sponge Hippospongia lachne.Therapeutic potential of targeting the oncogenic SHP2 phosphatase."PEST control": regulation of molecular barcodes by tyrosine phosphatases.Protein tyrosine phosphatases as potential therapeutic targets.A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery.Targeting a cryptic allosteric site for selective inhibition of the oncogenic protein tyrosine phosphatase Shp2 The SIX1-EYA transcriptional complex as a therapeutic target in cancer.Protein-tyrosine phosphatase 1B substrates and metabolic regulation Viewing serine/threonine protein phosphatases through the eyes of drug designers Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver.Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B.PTP1B: a new therapeutic target for Rett syndrome Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis.Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors.PTP1B: a simple enzyme for a complex world.VHR/DUSP3 phosphatase: structure, function and regulation.Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation.The extended human PTPome: a growing tyrosine phosphatase family.Modulation of VEGF receptor 2 signaling by protein phosphatases.Covalent inhibition of protein tyrosine phosphatases.Druggability analysis and classification of protein tyrosine phosphatase active sites.Sticking It to Cancer with Molecular Glue for SHP2 Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites.Vanadyl complexes with dansyl-labelled di-picolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies.1H-2,3-dihydroperimidine derivatives: a new class of potent protein tyrosine phosphatase 1B inhibitors.Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies.Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases.

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Small molecule tools for functional interrogation of protein tyrosine phosphatases

http://www.wikidata.org/entity/Q26852276

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Small molecule tools for functional interrogation of protein tyrosine phosphatases

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Small molecule tools for functional interrogation of protein tyrosine phosphatases

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Small molecule tools for functional interrogation of protein tyrosine phosphatases

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type

label

Small molecule tools for functional interrogation of protein tyrosine phosphatases

@ast

Small molecule tools for functional interrogation of protein tyrosine phosphatases

@en

Small molecule tools for functional interrogation of protein tyrosine phosphatases

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prefLabel

Small molecule tools for functional interrogation of protein tyrosine phosphatases

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Small molecule tools for functional interrogation of protein tyrosine phosphatases

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Small molecule tools for functional interrogation of protein tyrosine phosphatases

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J.1742-4658.2012.08718.X

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Small molecule tools for functional interrogation of protein tyrosine phosphatases

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Li-Fan Zeng

http://www.w3.org/2001/XMLSchema#string

Rongjun He

http://www.w3.org/2001/XMLSchema#string

Sheng Zhang

http://www.w3.org/2001/XMLSchema#string

Yantao He

http://www.w3.org/2001/XMLSchema#string

Zhong-Yin Zhang

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P2860

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase)

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

VE-PTP controls blood vessel development by balancing Tie-2 activity

GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis

Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence

Large-scale structural analysis of the classical human protein tyrosine phosphatome

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22816879

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3495087

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