Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases
about
Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrateThe autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunityCutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signalingLarge-scale structural analysis of the classical human protein tyrosine phosphatomeMetal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphataseThe role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasisSmall molecule tools for functional interrogation of protein tyrosine phosphatasesCrystal Structure of the Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights into Redox Regulation,Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Selective Inactivation of a Human Neuronal Silencing Phosphatase by a Small Molecule InhibitorIsothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of theYersinia pestisprotein tyrosine phosphatase YopHA Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune DiseasesThe catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodesHigh basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitisBiochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266WIdentification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approachDistinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype.Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.LYP inhibits T-cell activation when dissociated from CSK.Survey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects.In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation.Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes.A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acidsLymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.Covalent inhibition of the lymphoid tyrosine phosphatase.Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?Target-specific control of lymphoid-specific protein tyrosine phosphatase (Lyp) activityTherapeutic potential of targeting the oncogenic SHP2 phosphatase.CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitorsA combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitorsA facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase BSubstrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitorsCD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cellsHydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase betaRegulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomainDouble click reaction for the acquisition of a highly potent and selective mPTPB inhibitorRole of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammationEnhanced interrogation: emerging strategies for cell signaling inhibitionInhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity.
P2860
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P2860
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@ast
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@en
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@en-gb
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@nl
type
label
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@ast
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@en
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@en-gb
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@nl
prefLabel
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@ast
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@en
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@en-gb
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@nl
P2093
P2860
P356
P1476
Structure, inhibitor, and regu ...... licated in autoimmune diseases
@en
P2093
Andy Hudmon
Jin-Peng Sun
Xiaoling Guo
Zhong-Yin Zhang
P2860
P304
19767-19772
P356
10.1073/PNAS.0706233104
P407
P50
P577
2007-12-03T00:00:00Z