Synthetic lethal screens as a means to understand and treat MYC-driven cancers
about
MYC, Metabolism, and CancerMYC activation is a hallmark of cancer initiation and maintenanceDrugging the addict: non-oncogene addiction as a target for cancer therapyRole of MYC in B Cell Lymphomagenesis.Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cellsLinking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.MYC is a critical target of FBXW7Strategies to Inhibit Myc and Their Clinical ApplicabilityEnhancing the throughput and multiplexing capabilities of next generation sequencing for efficient implementation of pooled shRNA and CRISPR screens.Targeting MYC in cancer therapy: RNA processing offers new opportunities.An overview of MYC and its interactome.MicroRNA-based screens for synthetic lethal interactions with c-MycMulti-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer.Triple-negative breast cancer: investigating potential molecular therapeutic target.MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies.MYC, Metabolic Synthetic Lethality, and Cancer.Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functionsThe mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomasMelanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.Calcium signalling links MYC to NUAK1.Novel cooperative pathway of c-Myc and Furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers.MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.Functional precision medicine identifies novel druggable targets and therapeutic options in head and neck cancer.Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
P2860
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P2860
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
description
2014 nî lūn-bûn
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2014 թուականի Մարտին հրատարակուած գիտական յօդուած
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2014 թվականի մարտին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@ast
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@en
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@nl
type
label
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@ast
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@en
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@nl
prefLabel
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@ast
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@en
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@nl
P2093
P2860
P1476
Synthetic lethal screens as a means to understand and treat MYC-driven cancers
@en
P2093
B. Bernard
C. Grandori
I. S. Jang
S. Cermelli
P2860
P356
10.1101/CSHPERSPECT.A014209
P407
P577
2014-03-01T00:00:00Z