Nuclear export of proteins and drug resistance in cancer - Test2 - elhamkhani - TriplyDB

Nuclear export of proteins and drug resistance in cancer

Nuclear export of proteins and drug resistance in cancer

http://www.wikidata.org/entity/Q27012444

about

Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy Potential targets for ovarian clear cell carcinoma: a review of updates and future perspectives Structural Basis of Targeting the Exportin CRM1 in Cancer Multiple Export Mechanisms for mRNAs Nuclear transport of galectin-3 and its therapeutic implications The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus Genomic and molecular characterization of esophageal squamous cell carcinoma Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo.Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma.KPT-330 has antitumour activity against non-small cell lung cancer.Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.Atomic basis of CRM1-cargo recognition, release and inhibition Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Protein mislocalization: mechanisms, functions and clinical applications in cancer.KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma.Nuclear export mediated regulation of microRNAs: potential target for drug intervention.Targeting nucleocytoplasmic transport in cancer therapy Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study.Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenografts.shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines.NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles.LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins.XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models.Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic Cancer Routing of Biomolecules and Transgenes' Vectors in Nuclei of Oocytes The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation.

P2860

Q26764837-3ADE6CF0-399A-470F-B08C-75C4C017587F Q26775315-4A7DEEFD-67BD-46A7-A604-3AFCA90BEC46 Q26781513-E1573974-F869-4BD4-A7C1-5D096B9188DB Q26783595-76484A09-65C4-4040-84DA-ABB28056F361 Q26824889-1238C815-1C5C-4DE4-99C2-527064F34771 Q27026264-9E961AA8-E1D7-4AB5-BCA9-86DD698EF8F7 Q27307611-BC78BF4A-4144-459A-89B9-89CCC3B232FB Q27670981-4CA7106F-C824-4CDD-93BC-5875910B7792 Q27674083-4DDC9E7B-231E-41A5-BA8E-549EB4DDD347 Q27712238-F72423D9-EDA5-4264-B6AD-9797C06DC4E5 Q28114786-B22599D8-9DC2-470F-9B53-24BE3C6F2F52 Q28577939-E44905D1-0DC0-4787-AB5F-94A21B107561 Q28657686-C737EF02-B0E8-4B94-BBA4-77627FE52C5B Q30363986-9C2F9241-2BAA-470D-8330-AF79BCC866D1 Q30665952-1BB07940-46DB-4479-B0A1-CAE9FE63FA5A Q33430367-D90EAEDE-64B0-4411-9694-A6686CF6A939 Q33868512-EBA4E6DD-212B-4BD7-9B69-5456DF9A1D0B Q33918079-82234688-0A60-40E3-933E-9B762B212C39 Q33934010-D58E0D82-57E5-44FD-944E-CF661289DC09 Q33940712-A41E2262-78F8-4D8F-BAE3-D5F369F33BB5 Q33976883-58D9E29F-C92D-423B-A01A-26920D30F3B1 Q34076405-BD8FBE14-69AE-4F74-999E-12A0ECB6E5A5 Q34098446-C131E148-2FE0-4F30-BB10-0B9EBD796EED Q34204130-8FF4FEFC-3396-4B75-9C51-0AD2648C7532 Q34398166-A23320E4-2F58-4E63-A1A8-69C82D7404F6 Q34410193-843845F0-841C-4910-AF3F-BF1B997B621B Q35087639-D5DDE458-FD60-4296-BDA5-9D4FCB27BD8D Q35111192-76E3E4BF-F472-408F-AE00-4199B3B3B89E Q35171271-A26FB5BB-BFE6-4F3A-8FFF-212BE5AB730C Q35206543-FD2114B2-8E3A-4EF2-99DD-1D59E5091528 Q35261339-52D78C72-8EF5-4050-87C1-3494BD0E50BA Q35541125-99B0B864-AD58-4A1B-9F39-E97FB718B40A Q35602930-A700F116-0EE7-4178-B69C-FA7E1BAB6E92 Q35823090-C6352CD0-EDE8-4062-BF29-0F9319E89710 Q35843010-1A20C616-7C63-4673-A53C-6F12EE825CA9 Q35856215-1027E291-C890-4C5F-B13A-EA851244F37A Q35920569-7715B401-33FD-49D5-B892-4834446F7393 Q36078792-9663F168-66D6-4262-9C41-E1020B89256E Q36161007-4463CA50-E390-4ABD-BB2D-86AADDF3BAFB Q36182197-68CDEF0A-F7E2-4DBE-8B0A-4DB1FC56BA6B

P2860

Nuclear export of proteins and drug resistance in cancer

http://www.wikidata.org/entity/Q27012444

description

2012 nî lūn-bûn

@nan

2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Nuclear export of proteins and drug resistance in cancer

@ast

Nuclear export of proteins and drug resistance in cancer

@en

Nuclear export of proteins and drug resistance in cancer

@nl

type

label

Nuclear export of proteins and drug resistance in cancer

@ast

Nuclear export of proteins and drug resistance in cancer

@en

Nuclear export of proteins and drug resistance in cancer

@nl

prefLabel

Nuclear export of proteins and drug resistance in cancer

@ast

Nuclear export of proteins and drug resistance in cancer

@en

Nuclear export of proteins and drug resistance in cancer

@nl

P1433

Q27012444-84276FB6-551B-4180-B385-983B2540E5C7

P1476

Q27012444-68266E81-550A-470D-B3C2-C2B04D3423B7

P2093

Q27012444-3DE8B020-1BE2-41ED-A4F3-4F2F3882B678

Q27012444-9DF20E58-5A06-4D8D-8593-E030A47332C0

Q27012444-B6F443BC-D917-4A93-9D81-7A2B445CC0D8

P2860

Q27012444-0153924B-9ED2-48E8-BD53-EFB696018216

Q27012444-03AEA5D6-32A8-4074-ADEB-19574FBD0EAC

Q27012444-04092871-72C6-4521-937F-3B2340F15519

Q27012444-08531519-90C7-4565-A61D-A5B78B9F4057

Q27012444-090EBED9-FCEF-44C4-A6AD-53D8931B2333

Q27012444-09B08AC9-BDF4-4AD1-BBBE-3E41E1476AD5

Q27012444-0AE2075D-D310-4506-8435-A5F2F6589755

Q27012444-0F70EC51-B006-4AEE-909B-504DD8BF7282

Q27012444-127006BB-EF9B-4F41-9577-30DC551FCF47

Q27012444-12DEEBF6-D011-4B1C-9E09-7F5097B7E6BA

P304

Q27012444-ED028896-CBA7-4373-B5B1-D291B97929C6

P31

Q27012444-06D82FFC-03E4-42A9-8005-3C1FE0058153

P3181

Q27012444-1C35684F-4C1F-490D-B817-44CEEE1ADE50

P356

Q27012444-F25DB05C-6C33-4FF3-A090-E4AA9DF96024

P407

Q27012444-5AD961BD-363B-4817-9E56-5E1A24C68356

P433

Q27012444-C3AF90AF-0BF6-4FFD-861B-FA114E2FA2A8

P478

Q27012444-1279A2A0-7EE7-43BA-BE5D-1964D9529194

P577

Q27012444-5B825A90-A7C3-4288-9A10-227AE242910D

P5875

Q27012444-F04CCC2A-FF9F-4A0F-81AC-B2D634DA4EEB

P698

Q27012444-F4802A7C-3A19-4FC1-8903-75B30B412D0E

P932

Q27012444-A02C4C44-603A-487B-8154-54422D866F5D

P3181

P356

J.BCP.2011.12.016

P1433

Biochemical Pharmacology

P1476

Nuclear export of proteins and drug resistance in cancer

@en

P2093

Daniel M. Sullivan

http://www.w3.org/2001/XMLSchema#string

Jana Dawson

http://www.w3.org/2001/XMLSchema#string

Joel G. Turner

http://www.w3.org/2001/XMLSchema#string

P2860

Interaction of tumor cells with the microenvironment

Cellular roles of dna topoisomerases: a molecular perspective

Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

Mapping nucleolar localization sequences of 1A6/DRIM

Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma

A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein

Rules for nuclear localization sequence recognition by karyopherin beta 2

Structural basis for leucine-rich nuclear export signal recognition by CRM1

P304

1021-32

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1683819

http://www.w3.org/2001/XMLSchema#string

P356

10.1016/J.BCP.2011.12.016

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

83

http://www.w3.org/2001/XMLSchema#string

P577

2012-04-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51973234

http://www.w3.org/2001/XMLSchema#string

P698

22209898

http://www.w3.org/2001/XMLSchema#string

P932

4521586

http://www.w3.org/2001/XMLSchema#string