Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia - Test2 - elhamkhani - TriplyDB

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

http://www.wikidata.org/entity/Q27674083

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A structurally plastic ribonucleoprotein complex mediates post-transcriptional gene regulation in HIV-1 Structural Basis of Targeting the Exportin CRM1 in Cancer Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition The interaction of CRM1 and the nuclear pore protein Tpr Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1 Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus Genomic and molecular characterization of esophageal squamous cell carcinoma Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo.Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropism Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors Phase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma.Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model KPT-330 has antitumour activity against non-small cell lung cancer.Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.Atomic basis of CRM1-cargo recognition, release and inhibition Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells.Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer Protein mislocalization: mechanisms, functions and clinical applications in cancer.KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma.PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.Nuclear export mediated regulation of microRNAs: potential target for drug intervention.Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents SINE (selective inhibitor of nuclear export)--translational science in a new class of anti-cancer agents Nucleo-cytoplasmic transport as a therapeutic target of cancer Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study.shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines.LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins.Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential.

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Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

http://www.wikidata.org/entity/Q27674083

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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P2860

Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp

An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1

Structural basis for leucine-rich nuclear export signal recognition by CRM1

CRM1-mediated recycling of snurportin 1 to the cytoplasm

Ran-dependent nuclear export mediators: a structural perspective

Nuclear export of proteins and drug resistance in cancer

Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

p53-Dependent anticancer effects of leptomycin B on lung adenocarcinoma

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