Structural basis for leucine-rich nuclear export signal recognition by CRM1
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Emerging roles for the influenza A virus nuclear export protein (NEP)Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin αDOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcriptionAn allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1Structural basis for the nuclear export activity of Importin13Capturing Biological Activity in Natural Product Fragments by Chemical SynthesisStructural Basis of Targeting the Exportin CRM1 in CancerRan-dependent nuclear export mediators: a structural perspectiveNuclear export of proteins and drug resistance in cancerTargeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal TransitionReversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirAThe interaction of CRM1 and the nuclear pore protein TprConformational selection in the recognition of the snurportin importin beta binding domain by importin betaNES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding DomainAntileukemic activity of nuclear export inhibitors that spare normal hematopoietic cellsSelective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemiaStructural basis for cooperativity of CRM1 export complex formationNuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignanciesCex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex.Nuclear import of UBL-domain protein Mdy2 is required for heat-induced stress response in Saccharomyces cerevisiae.A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.Antiviral Efficacy of Verdinexor In Vivo in Two Animal Models of Influenza A Virus InfectionThe export receptor Crm1 forms a dimer to promote nuclear export of HIV RNAEvolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replicationVerdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo.A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export.Nucleocytoplasmic shuttling of the HSV-2 serine/threonine kinase Us3Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropismCombining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex.The importin beta binding domain modulates the avidity of importin beta for the nuclear pore complexThe nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and DrosophilaAtomic basis of CRM1-cargo recognition, release and inhibitionThe importin β binding domain as a master regulator of nucleocytoplasmic transportKPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma.Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinaseA novel N-terminal domain may dictate the glucose response of Mondo proteins.Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4.Identification of a novel nucleocytoplasmic shuttling RNA helicase of trypanosomes.
P2860
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P2860
Structural basis for leucine-rich nuclear export signal recognition by CRM1
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@ast
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@en
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@nl
type
label
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@ast
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@en
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@nl
prefLabel
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@ast
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@en
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structural basis for leucine-rich nuclear export signal recognition by CRM1
@en
P2093
Anindita Biswas
Hongmei Gu
Katherine E Süel
Laurie K Jackson
Rita Martinez
Xiuhua Dong
Yuh Min Chook
P2860
P2888
P304
P3181
P356
10.1038/NATURE07975
P407
P577
2009-04-30T00:00:00Z
P5875
P6179
1009393134