about
Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1.Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.Role of MYC in B Cell Lymphomagenesis.Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells.MYC Deregulation in Primary Human Cancers.Binding cavities and druggability of intrinsically disordered proteins.Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion.Strategies to Inhibit Myc and Their Clinical ApplicabilityMYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation.MicroRNA-based screens for synthetic lethal interactions with c-MycJQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer.Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine effortsLysine-52 stabilizes the MYC oncoprotein through an SCF(Fbxw7)-independent mechanism.Drugging the 'undruggable' cancer targets.Targeting MYC: is it getting any easier?The MYCN Protein in Health and Disease.MYC Modulation around the CDK2/p27/SKP2 AxisFamily matters: How MYC family oncogenes impact small cell lung cancer.A quantitative, surface plasmon resonance-based approach to evaluating DNA binding by the c-Myc oncoprotein and its disruption by small molecule inhibitors.Small molecules remain on target for c-Myc.In silico structure-based approaches to discover protein-protein interaction-targeting drugs.Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction.The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues.Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells.MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
P2860
Q27349131-CB9B1EB9-8C7B-4860-AD5E-F06C1442E7F4Q30278518-82BF4CE8-74BF-4D12-B354-D714FC3DCCC0Q33608499-4228E31E-828A-4C6D-AE3D-8E4158D91A48Q33728292-BFD2F527-18C6-43D7-B10B-520DAC9D6613Q33836755-6486BD2A-C998-484E-A24F-94225374E882Q35571730-ACDD6B6A-E52D-4030-B999-823EA71C0946Q35601876-D21AC3B6-84FF-4BC0-8E9A-5D6FD6D30E5DQ35697342-2F779D88-0BAE-43F4-9FC9-C30F7DF4633BQ35937111-9994261B-4185-4C70-90B8-1B617A7A0899Q35981250-B5A63D40-A4F7-48B8-B630-8B9A7A640B0BQ36140644-1912A8D3-F80A-4976-943D-5D7DDFBAC6E3Q36303678-3E25D184-4F25-4DB9-B395-115B56E7E263Q37118720-F00B725E-B55D-41E8-99A9-0953A5ED2ACCQ37495218-87D42BAC-D9D8-4DC7-B76F-EE531A8C9340Q37687075-F6FE203E-6292-4554-8BE6-C14C1DBD21F5Q37733990-A92D4D14-DE69-4694-BF1C-C5F225FCCEDFQ38625813-BD4B19C7-D422-4C24-9624-23A5249C7825Q38667658-C1FD4D11-46DE-4F89-9107-80DE3E30DFF8Q38819081-B5763ACB-768A-4EAF-8CDB-BDA97905D6C7Q39208675-76EF38E0-D6EE-4DD7-9100-52A3AC8B1401Q39406924-D0409F26-AF73-43E3-9858-D5830E88BD9BQ39454070-D211E120-92E6-4A20-962F-23C09A727D23Q41880916-ACD52C2E-3AD8-41EA-9A67-FFAC8CB82B69Q42329646-02CCE28C-7513-42BE-9B1F-E2C328B8E755Q47960281-70A5E821-5A2A-47FD-8E7F-4C922925ACC7Q52596648-75007305-BA44-4ECC-B011-52F9E77281B4Q52715807-25C5DB55-20BC-4C94-9DD1-D7E083FD1BDEQ55049313-03F79B31-DD47-47F2-97D5-D8C84AE79822Q58327191-DD1C83E8-2447-4F9E-A04F-A9D63FAC4D94
P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Small-molecule inhibitors of the Myc oncoprotein
@ast
Small-molecule inhibitors of the Myc oncoprotein
@en
Small-molecule inhibitors of the Myc oncoprotein
@nl
type
label
Small-molecule inhibitors of the Myc oncoprotein
@ast
Small-molecule inhibitors of the Myc oncoprotein
@en
Small-molecule inhibitors of the Myc oncoprotein
@nl
prefLabel
Small-molecule inhibitors of the Myc oncoprotein
@ast
Small-molecule inhibitors of the Myc oncoprotein
@en
Small-molecule inhibitors of the Myc oncoprotein
@nl
P2860
P1476
Small-molecule inhibitors of the Myc oncoprotein
@en
P2093
Edward V. Prochownik
Steven Fletcher
P2860
P304
P356
10.1016/J.BBAGRM.2014.03.005
P407
P577
2015-05-01T00:00:00Z