Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
about
X-ray structure of dopamine transporter elucidates antidepressant mechanismThe binding sites for cocaine and dopamine in the dopamine transporter overlapAntidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structuresComparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognitionMonoamine transporters: insights from molecular dynamics simulationsInsights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDATDesigning modulators of monoamine transporters using virtual screening techniquesVisualizing functional motions of membrane transporters with molecular dynamics simulationsBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterHow LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transportersSLC transporters as therapeutic targets: emerging opportunitiesSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusA steered molecular dynamics study of binding and translocation processes in the GABA transporterA conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling.Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologueStructure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family TransporterA competitive inhibitor traps LeuT in an open-to-out conformation.Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformationSubstrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologuePentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepinesInsights into transport mechanism from LeuT engineered to transport tryptophanX-ray structures of LeuT in substrate-free outward-open and apo inward-open statesStructures of LeuT in bicelles define conformation and substrate binding in a membrane-like contextStructural basis for action by diverse antidepressants on biogenic amine transportersStructural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transportersGeomfinder: a multi-feature identifier of similar three-dimensional protein patterns: a ligand-independent approachTransient formation of water-conducting states in membrane transportersThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsLigand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulationsThermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound ConformationMapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular DynamicsDirected evolution reveals hidden properties of VMAT, a neurotransmitter transporterDirect assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMRExploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics StudyStructures of membrane proteins.Substrate binding and formation of an occluded state in the leucine transporter.The Concise Guide to PHARMACOLOGY 2013/14: transporters.4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter.Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.
P2860
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P2860
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@ast
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@en
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@nl
type
label
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@ast
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@en
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@nl
prefLabel
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@ast
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@en
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@nl
P3181
P356
P1433
P1476
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
@en
P2093
Atsuko Yamashita
Satinder K Singh
P2888
P3181
P356
10.1038/NATURE06038
P407
P50
P577
2007-08-23T00:00:00Z
P6179
1048188778