X-ray structure of dopamine transporter elucidates antidepressant mechanism - Test2 - elhamkhani - TriplyDB

X-ray structure of dopamine transporter elucidates antidepressant mechanism

X-ray structure of dopamine transporter elucidates antidepressant mechanism

http://www.wikidata.org/entity/Q24612997

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Monoamine transporters: insights from molecular dynamics simulations Insights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDAT Designing modulators of monoamine transporters using virtual screening techniques The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter SLC transporters as therapeutic targets: emerging opportunities Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Neurotransmitter and psychostimulant recognition by the dopamine transporter.Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling.Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs.Geomfinder: a multi-feature identifier of similar three-dimensional protein patterns: a ligand-independent approach Transporter oligomerization: form and function Rapid Bioinformatic Identification of Thermostabilizing Mutations Enhancing Protein Expression in HEK-293 Cells by Lowering Culture Temperature Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR Targeting Neuroblastoma Cell Surface Proteins: Recommendations for Homology Modeling of hNET, ALK, and TrkB Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study Cholesterol binding to ion channels A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter Molecular basis of the dominant negative effect of a glycine transporter 2 mutation associated with hyperekplexia.Thermal Stability of Dopamine Transporters.PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy.Seven perspectives on GPCR H/D-exchange proteomics methods Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters.Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.Identification of novel inhibitors of the amino acid transporter B0 AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes.Serotonin-induced down-regulation of cell surface serotonin transporter Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter.Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing

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P2860

X-ray structure of dopamine transporter elucidates antidepressant mechanism

http://www.wikidata.org/entity/Q24612997

description

2013 nî lūn-bûn

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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

@zh-my

2013年学术文章

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2013年學術文章

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name

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@ast

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@en

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@nl

type

label

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@ast

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@en

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@nl

prefLabel

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@ast

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@en

X-ray structure of dopamine transporter elucidates antidepressant mechanism

@nl

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X-ray structure of dopamine transporter elucidates antidepressant mechanism

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Aravind Penmatsa

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Kevin H Wang

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P2860

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

MolProbity: all-atom structure validation for macromolecular crystallography

The binding sites for cocaine and dopamine in the dopamine transporter overlap

Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures

BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies

Processing of X-ray diffraction data collected in oscillation mode

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

A competitive inhibitor traps LeuT in an open-to-out conformation.

Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

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10.1038/NATURE12533

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24037379

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