A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.
about
The P42 peptide and Peptide-based therapies for Huntington's diseaseSerine 421 regulates mutant huntingtin toxicity and clearance in mice.Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch.Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.ASPsiRNA: A Resource of ASP-siRNAs Having Therapeutic Potential for Human Genetic Disorders and Algorithm for Prediction of Their Inhibitory Efficacy.Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice.Palmitoylation of caspase-6 by HIP14 regulates its activation.Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity.Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.Therapy development in Huntington disease: From current strategies to emerging opportunities.
P2860
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P2860
A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
A Huntingtin-based peptide inh ...... motor and behavioral deficits
@nl
A Huntingtin-based peptide inh ...... motor and behavioral deficits.
@ast
A Huntingtin-based peptide inh ...... motor and behavioral deficits.
@en
type
label
A Huntingtin-based peptide inh ...... motor and behavioral deficits
@nl
A Huntingtin-based peptide inh ...... motor and behavioral deficits.
@ast
A Huntingtin-based peptide inh ...... motor and behavioral deficits.
@en
prefLabel
A Huntingtin-based peptide inh ...... motor and behavioral deficits
@nl
A Huntingtin-based peptide inh ...... motor and behavioral deficits.
@ast
A Huntingtin-based peptide inh ...... motor and behavioral deficits.
@en
P2093
P2860
P356
P1476
A Huntingtin-based peptide inh ...... motor and behavioral deficits.
@en
P2093
Adi Shruster
Dagmar E Ehrnhoefer
Daniel Offen
Israel Aharony
Sonia Franciosi
Xiaofan Qiu
P2860
P304
P356
10.1093/HMG/DDV023
P407
P577
2015-01-23T00:00:00Z