HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
about
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domainClathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteinsHuntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitorsRecruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner HippiHIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chainReplacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell deathHuntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterationsHuntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptorsHuntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivoA human HAP1 homologue. Cloning, expression, and interaction with huntingtinScyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde trafficEndoplasmic reticulum stress: cell life and death decisions.Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's diseaseHuntingtin in health and diseaseRNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery.The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesisThe localization and interactions of huntingtinA Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domainNovel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast.Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast.Sla1p is a functionally modular component of the yeast cortical actin cytoskeleton required for correct localization of both Rho1p-GTPase and Sla2p, a protein with talin homology.Sla2p is associated with the yeast cortical actin cytoskeleton via redundant localization signals.Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chainAberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtinExpression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin IIHuntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survivalHuntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal traffickingHuntington's disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcriptionHippi is essential for node cilia assembly and Sonic hedgehog signalingDeletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitroDisruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor traffickingHAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic miceAn actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesiclesThe actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitroHAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neuronsHuntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansionInactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.Stage-specific gene expression in early differentiating oligodendrocytes.
P2860
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P2860
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@ast
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@en
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@en-gb
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@nl
type
label
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@ast
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@en
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@en-gb
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@nl
prefLabel
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@ast
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@en
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@en-gb
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@nl
P2093
P2860
P921
P356
P1433
P1476
HIP1, a human homologue of S. ...... ciated huntingtin in the brain
@en
P2093
C Wellington
I Kanazawa
K McCutcheon
K Nishiyama
M A Kalchman
M R Hayden
P2860
P2888
P356
10.1038/NG0597-44
P407
P577
1997-05-01T00:00:00Z
P6179
1012110297