sameAs
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domainA gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner HippiHIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chainThe palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's diseaseMutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathyHuntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteinsIdentification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic IsolatesPerception, experience, and response to genetic discrimination in Huntington disease: the international RESPOND-HD studyThe Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesisPalmitoylation of huntingtin by HIP14 is essential for its trafficking and functionGender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infectionAge-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington diseaseAccurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 geneA Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosisHuntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genesMutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosisThe first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblingsLoss of huntingtin-mediated BDNF gene transcription in Huntington's diseaseA role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin bindingEfflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 geneHIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosisVariations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosisThe murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3Differential modulation of endotoxin responsiveness by human caspase-12 polymorphismsGenetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapyCaspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tractHuntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chainTargeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotesGenomic organization of the human alpha-adducin gene and its alternately spliced isoformsInhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleusDeficiency of ABCA1 impairs apolipoprotein E metabolism in brainHippi is essential for node cilia assembly and Sonic hedgehog signalingElevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease miceBeta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatmentDisruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor traffickingAllele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients
P50
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P50
description
Canadees neurowetenschapper
@nl
South African - Canadian physician
@en
dochtúir
@ga
kanadischer Neurowissenschaftler, Genetiker und Hochschullehrer
@de
medico
@it
հետազոտող
@hy
name
Michael R. Hayden
@ast
Michael R. Hayden
@ca
Michael R. Hayden
@de
Michael R. Hayden
@en
Michael R. Hayden
@es
Michael R. Hayden
@fr
Michael R. Hayden
@ga
Michael R. Hayden
@nl
Michael R. Hayden
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Michael R. Hayden
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type
label
Michael R. Hayden
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Michael R. Hayden
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Michael R. Hayden
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Michael R. Hayden
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Michael R. Hayden
@es
Michael R. Hayden
@fr
Michael R. Hayden
@ga
Michael R. Hayden
@nl
Michael R. Hayden
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Michael R. Hayden
@sq
altLabel
Hayden M
@en
Hayden M. R.
@en
Hayden M.
@en
Hayden MR
@en
Hayden
@en
M Hayden
@en
M R Hayden
@en
M. Hayden
@en
M. R. Hayden
@en
Michael Hayden
@en
prefLabel
Michael R. Hayden
@ast
Michael R. Hayden
@ca
Michael R. Hayden
@de
Michael R. Hayden
@en
Michael R. Hayden
@es
Michael R. Hayden
@fr
Michael R. Hayden
@ga
Michael R. Hayden
@nl
Michael R. Hayden
@sl
Michael R. Hayden
@sq
P106
P108
P166
P1006
P214
P227
P244
P269
P1006
P1053
D-8581-2011
P1315
P166
P19
P21
P213
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