High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain
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Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismMouse Genetic Models of Human Brain DisordersThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseLRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's DiseaseTen years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinicProgressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceConditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegenerationDifferential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodentsAbrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.Non-motor and motor features in LRRK2 transgenic mice.Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.LRRK2 mutations and neurotoxicant susceptibilityDivergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.Models of α-synuclein aggregation in Parkinson's disease.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.LRRK2 Promotes Tau Accumulation, Aggregation and Release.LRRKing up the right trees? On figuring out the effects of mutant LRRK2 and other Parkinson's disease-related genes.Mechanisms of Mutant LRRK2 Neurodegeneration.Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.Dangerous duet: LRRK2 and α-synuclein jam at CMA.LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.
P2860
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P2860
High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain
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2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
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2012年论文
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name
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@ast
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@en
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@nl
type
label
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@ast
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@en
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@nl
prefLabel
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@ast
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@en
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@nl
P2093
P2860
P3181
P1433
P1476
High LRRK2 levels fail to indu ...... synucleinopathy in mouse brain
@en
P2093
Andreas Weiss
Carmen Barske
Christine Stemmelen
Daniela Stauffer
Franziska Mayer
Giorgio Rovelli
Michael Bidinosti
Nella Vidotto
P Herman van der Putten
Peter Schmid
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0036581
P407
P577
2012-01-01T00:00:00Z