Kinase activity of mutant LRRK2 mediates neuronal toxicity
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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Dopamine release in the basal gangliaThe Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activityLeucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADPRibosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's diseaseLRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressExpression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model systemMKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityIdentification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screenLRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1The R1441C mutation of LRRK2 disrupts GTP hydrolysisLeucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi exportARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutationsInsight into the mode of action of the LRRK2 Y1699C pathogenic mutantLRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative studyArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyGTP binding controls complex formation by the human ROCO protein MASL1The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sitesAn early endosome regulator, Rab5b, is an LRRK2 kinase substrateMembrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylationMutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathwaysLRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodiesThe Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylationThe Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegenerationMutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal deathDysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegansLRRK2 phosphorylates novel tau epitopes and promotes tauopathyParkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domainG2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarizationRole of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cellsIntrabody and Parkinson's diseaseActivation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designMouse models of Parkinson's disease associated with mitochondrial dysfunction
P2860
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P2860
Kinase activity of mutant LRRK2 mediates neuronal toxicity
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@ast
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@en
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@en-gb
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@nl
type
label
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@ast
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@en
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@en-gb
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@nl
prefLabel
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@ast
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@en
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@en-gb
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@nl
P2093
P921
P3181
P356
P1433
P1476
Kinase activity of mutant LRRK2 mediates neuronal toxicity
@en
P2093
Haibing Jiang
Valina L Dawson
Wanli W Smith
P2888
P304
P3181
P356
10.1038/NN1776
P407
P577
2006-10-01T00:00:00Z
P5875
P6179
1001879206