Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin
about
p38 MAPK and PI3K/AKT Signalling Cascades inParkinson's DiseaseActivation of the E3 ubiquitin ligase Parkin.The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activityStructural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylationE2 superfamily of ubiquitin-conjugating enzymes: constitutively active or activated through phosphorylation in the catalytic cleft.A Ubl/ubiquitin switch in the activation of ParkinPosttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain FormationInteraction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.Modeling and fitting protein-protein complexes to predict change of binding energyConnecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes.Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.Parkin and PINK1 functions in oxidative stress and neurodegeneration.Ubiquitin and Parkinson's disease through the looking glass of genetics.Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy.Mechanism of phospho-ubiquitin-induced PARKIN activation.UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN.Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy.Protein molecular modeling techniques investigating novel TAB2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational family.Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin.Whole Exome Sequencing and Molecular Modeling of a Missense Variant in TNFAIP3 That Segregates with Disease in a Family with Chronic Urticaria and Angioedema.
P2860
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P2860
Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@ast
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@en
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@nl
type
label
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@ast
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@en
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@nl
prefLabel
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@ast
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@en
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@nl
P2860
P50
P3181
P1476
Phosphorylation by PINK1 relea ...... the E3 ubiquitin ligase Parkin
@en
P2860
P304
P3181
P356
10.1371/JOURNAL.PCBI.1003935
P4011
4bf8dbf0bbf52fb9e8ec6432570f4689a997cad3
P407
P50
P577
2014-11-01T00:00:00Z