High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
about
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondriaCross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseMitochondrial targets for pharmacological intervention in human diseaseThe three 'P's of mitophagy: PARKIN, PINK1, and post-translational modificationsMitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infectionPhosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase ParkinDominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and MetastasisActivation of the E3 ubiquitin ligase Parkin.Targeting Pink1-Parkin-mediated mitophagy for treating liver injuryChaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetesMitophagy: Basic Mechanism and Potential Role in Kidney DiseasesMitochondrial dynamics and mitochondrial quality controlTeaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approachesMitophagy mechanisms and role in human diseasesPubChem BioAssay: 2017 updatePINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activityHigh-throughput in situ cell electroporation microsystem for parallel delivery of single guide RNAs into mammalian cellsAn interactive web-based application for Comprehensive Analysis of RNAi-screen DataGenome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastomaMitochondrial genome maintenance in health and disease.Keeping the immune system in check: a role for mitophagy.A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differentlyTissue distribution, gender- and genotype-dependent expression of autophagy-related genes in avian species.The A Allele of the Single-Nucleotide Polymorphism rs630923 Creates a Binding Site for MEF2C Resulting in Reduced CXCR5 Promoter Activity in B-Cell Lymphoblastic Cell Lines.Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Genome-scale CRISPR-Cas9 knockout and transcriptional activation screeningConcise review: modeling central nervous system diseases using induced pluripotent stem cellsPubChem applications in drug discovery: a bibliometric analysisQuantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble.Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.Deep Imaging: the next frontier in microscopy.MitoFates: improved prediction of mitochondrial targeting sequences and their cleavage sites.High-throughput functional genomics using CRISPR-Cas9.The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation.High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis.Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagyThe roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease
P2860
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P248
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P2860
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@ast
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@en
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@en-gb
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@nl
type
label
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@ast
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@en
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@en-gb
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@nl
prefLabel
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@ast
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@en
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@en-gb
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@nl
P2093
P2860
P3181
P356
P1433
P1476
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
@en
P2093
Chiu-Hui Huang
Danielle A Sliter
Eugen Buehler
Koji Yamano
Lesley A Kane
Rajarshi Guha
Richard J Youle
Sabrina M Heman-Ackah
Scott E Martin
Tara Hessa
P2860
P2888
P304
P3181
P356
10.1038/NATURE12748
P407
P577
2013-11-24T00:00:00Z
P6179
1047241961