PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
about
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondriaGuidelines for the use and interpretation of assays for monitoring autophagyGenetic perspective on the role of the autophagy-lysosome pathway in Parkinson diseaseGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cellsParkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's diseaseImage-based genome-wide siRNA screen identifies selective autophagy factorsUbiquitin is phosphorylated by PINK1 to activate parkinPresenilin-1 regulates the expression of p62 to govern p62-dependent tau degradationPINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityThe mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 traffickingThe mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagyMUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkinMitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyp62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for bothSPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasisMitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cellsAMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagyPhosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neuronsThe LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella TyphimuriumAutoregulation of Parkin activity through its ubiquitin-like domainThreonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagyHigh-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagyCytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagyUSP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondriaThe Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagyHexokinase activity is required for recruitment of parkin to depolarized mitochondriaHsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagyPossible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality controlMieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondriaBroad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagyStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionPGC-1α, a potential therapeutic target for early intervention in Parkinson's diseaseAutophagy, mitochondria and oxidative stress: cross-talk and redox signallingMutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neuronsMultiple Roles of the Small GTPase Rab7Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's DiseaseMitochondrial dysfunction in Parkinson's disease
P2860
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P2860
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@ast
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@en
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@en-gb
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@nl
type
label
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@ast
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@en
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@en-gb
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@nl
prefLabel
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@ast
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@en
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@en-gb
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@nl
P2093
P50
P3181
P356
P1433
P1476
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
@en
P2093
Diana Skujat
Oliver C Rothfuss
Philipp J Kahle
Sven Geisler
P2888
P304
P356
10.1038/NCB2012
P407
P577
2010-01-24T00:00:00Z
P5875
P6179
1021281910