Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells - Test2 - elhamkhani - TriplyDB

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

http://www.wikidata.org/entity/Q29617924

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2 Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4 Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure.Chromosomal instability and cancer: a complex relationship with therapeutic potential Unbalanced replication as a major source of genetic instability in cancer cells Abscission checkpoint control: stuck in the middle with Aurora B When 2+2=5: the origins and fates of aneuploid and tetraploid cells Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy Myosins as fundamental components during tumorigenesis: diverse and indispensable Genome management and mismanagement--cell-level opportunities and challenges of whole-genome duplication New Auroras on the Roles of the Chromosomal Passenger Complex in Cytokinesis: Implications for Cancer Therapies Targeting the Mitotic Catastrophe Signaling Pathway in Cancer The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability Centrosomes, chromosome instability (CIN) and aneuploidy DNA damage associated with mitosis and cytokinesis failure Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells Mitochondria-cytoskeleton associations in mammalian cytokinesis.Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Fibronectin assembly in the crypts of cytokinesis-blocked multilobular cells promotes anchorage-independent growth A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole Urochordate ascidians possess a single isoform of Aurora kinase that localizes to the midbody via TPX2 in eggs and cleavage stage embryos Essential role for a novel population of binucleated mammary epithelial cells in lactation.Clustered Intracellular Salmonella enterica Serovar Typhimurium Blocks Host Cell Cytokinesis.A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity.The c-Myc target glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cells

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

http://www.wikidata.org/entity/Q29617924

description

2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

@ast

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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type

label

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

@ast

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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prefLabel

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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Bandi M

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Bronson RT

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Fujiwara T

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Ivanova EV

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Nitta M

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Pellman D

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P2860

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

Centrosome amplification drives chromosomal instability in breast tumor development.

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

Polyploids require Bik1 for kinetochore-microtubule attachment.

Met, metastasis, motility and more

From polyploidy to aneuploidy, genome instability and cancer

Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2

New functions for the matrix metalloproteinases in cancer progression

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1614876

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10.1038/NATURE04217

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7544547

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1043261736

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16222300

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