An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques
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Advances in HIV microbicide developmentMicrobicides: topical prevention against HIVSIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humansA Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3HSV-2-driven increase in the expression of α4β7 correlates with increased susceptibility to vaginal SHIV(SF162P3) infectionA Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex VivoExposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaquesIncreased Dapivirine tissue accumulation through vaginal film codelivery of dapivirine and Tenofovir.Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes.In vitro and in vivo evaluation of two carrageenan-based formulations to prevent HPV acquisition.The emerging profile of cross-resistance among the nonnucleoside HIV-1 reverse transcriptase inhibitors.A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explantsShort communication: a repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicidesThe nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques.A potent combination microbicide that targets SHIV-RT, HSV-2 and HPVMultipurpose prevention technologies: biomedical tools to prevent HIV-1, HSV-2, and unintended pregnancies.Non-specific microbicide product development: then and nowAn intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaquesAlternative divalent cations (Zn²⁺, Co²⁺, and Mn²⁺) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity.Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge.MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model.Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide.Low Frequency of Drug-Resistant Variants Selected by Long-Acting Rilpivirine in Macaques Infected with Simian Immunodeficiency Virus Containing HIV-1 Reverse Transcriptase.A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection.A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancyCharacterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.In search of the optimal delivery method for anti-HIV microbicides: are intravaginal rings the way forward?Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques.Sustained release of the candidate antiretroviral peptides T-1249 and JNJ54310516-AFP from a rod insert vaginal ringA modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo.In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical MucosaFirst-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics.A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge.MIV-150-containing intravaginal rings protect macaque vaginal explants against SHIV-RT infection.HIV sexual transmission and microbicides.A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea]).Current and future microbicide approaches aimed at preventing HIV infection in women.Herpes simplex virus and HIV: genital infection synergy and novel approaches to dual prevention.Vaginal microbicides and their delivery platforms.
P2860
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P2860
An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@ast
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@en
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@nl
type
label
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@ast
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@en
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@nl
prefLabel
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@ast
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@en
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@nl
P2093
P2860
P3181
P1433
P1476
An antiretroviral/zinc combina ...... nal SHIV infection in macaques
@en
P2093
Agegnehu Gettie
Aixa Rodriguez
Anne Chudolij
Ciby J Abraham
James Blanchard
Jeffrey D Lifson
Jessica Kenney
Jose A Fernández-Romero
Larisa Kizima
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0015835
P407
P577
2011-01-01T00:00:00Z