Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes.
about
Temperature-sensitive mutations for live-attenuated Rift Valley fever vaccines: implications from other RNA virusesRecombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys.A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient miceNuclear Localization of Flavivirus RNA Synthesis in Infected CellsCharacterization of a small plaque variant of West Nile virus isolated in New York in 2000Evaluation of St. Louis encephalitis virus/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeysPhase I clinical evaluation of rDEN4Delta30-200,201: a live attenuated dengue 4 vaccine candidate designed for decreased hepatotoxicityAnalysis of Flavivirus NS5 Methyltransferase Cap BindingCrystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral ReplicationFocus on flaviviruses: current and future drug targetsPhase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult VolunteersA Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation ActivitiesMurine Efficacy and Pharmacokinetic Evaluation of the Flaviviral NS5 Capping Enzyme 2-Thioxothiazolidin-4-One Inhibitor BG-323A brief review on dengue molecular virology, diagnosis, treatment and prevalence in PakistanRNA interference modulates replication of dengue virus in Drosophila melanogaster cellsA fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-dependent RNA polymerase.The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome.Comparison of genotypes I and III in Japanese encephalitis virus reveals distinct differences in their genetic and host diversity.A 3' terminal stem-loop structure in Nodamura virus RNA2 forms an essential cis-acting signal for RNA replication.Construction of a dengue virus type 4 reporter replicon and analysis of temperature-sensitive mutations in non-structural proteins 3 and 5.Replacement of the 3' untranslated variable region of mosquito-borne dengue virus with that of tick-borne Langat virus does not alter vector specificity.Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccinePatterns of epistasis in RNA viruses: a review of the evidence from vaccine design.Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase InterfaceTargeted mutagenesis as a rational approach to dengue virus vaccine development.Genetic analysis of Murine hepatitis virus nsp4 in virus replicationThe L, M, and S Segments of Rift Valley Fever Virus MP-12 Vaccine Independently Contribute to a Temperature-Sensitive Phenotype.Genetic and phenotypic characterization of sylvatic dengue virus type 2 strains.Replacement of conserved or variable sequences of the mosquito-borne dengue virus 3' UTR with homologous sequences from Modoc virus does not change infectivity for mosquitoesSerotype-specific differences in dengue virus non-structural protein 5 nuclear localizationRecent progress in dengue vaccine development.Flavivirus RNA synthesis in vitroMutagenesis of the dengue virus type 2 NS5 methyltransferase domain.The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals.
P2860
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P2860
Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Paired Charge-to-Alanine Mutag ...... d Mouse Attenuation Phenotypes
@nl
Paired charge-to-alanine mutag ...... mouse attenuation phenotypes.
@ast
Paired charge-to-alanine mutag ...... mouse attenuation phenotypes.
@en
type
label
Paired Charge-to-Alanine Mutag ...... d Mouse Attenuation Phenotypes
@nl
Paired charge-to-alanine mutag ...... mouse attenuation phenotypes.
@ast
Paired charge-to-alanine mutag ...... mouse attenuation phenotypes.
@en
prefLabel
Paired Charge-to-Alanine Mutag ...... d Mouse Attenuation Phenotypes
@nl
Paired charge-to-alanine mutag ...... mouse attenuation phenotypes.
@ast
Paired charge-to-alanine mutag ...... mouse attenuation phenotypes.
@en
P2093
P2860
P1433
P1476
Paired charge-to-alanine mutag ...... mouse attenuation phenotypes.
@en
P2093
Brian R Murphy
Joseph E Blaney
Kathryn A Hanley
P2860
P304
P356
10.1128/JVI.76.2.525-531.2002
P577
2002-01-01T00:00:00Z