Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4
about
Ecuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus FlavivirusFunctions of the 3' and 5' genome RNA regions of members of the genus FlavivirusEndothelial cells in dengue hemorrhagic feverFever versus fever: the role of host and vector susceptibility and interspecific competition in shaping the current and future distributions of the sylvatic cycles of dengue virus and yellow fever virusUnderstanding the dengue viruses and progress towards their controlIdentification of Mutated Cyclization Sequences That Permit Efficient Replication of West Nile Virus Genomes: Use in Safer Propagation of a Novel Vaccine CandidateStructural and Functional Studies of the Promoter Element for Dengue Virus RNA ReplicationPhase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult VolunteersPossible Roles of New Mutations Shared by Asian and American Zika VirusesMolecular archaeology of Flaviviridae untranslated regions: duplicated RNA structures in the replication enhancer of flaviviruses and pestiviruses emerged via convergent evolutionA novel single-dose dengue subunit vaccine induces memory immune responsesVero cell platform in vaccine production: moving towards cell culture-based viral vaccines.Issues related to recent dengue vaccine development.The 5' and 3' Untranslated Regions of the Flaviviral Genome.Bioinformatics in new generation flavivirus vaccines.A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis.A single dose of the DENV-1 candidate vaccine rDEN1Δ30 is strongly immunogenic and induces resistance to a second dose in a randomized trial.Substitution of NS5 N-terminal domain of dengue virus type 2 RNA with type 4 domain caused impaired replication and emergence of adaptive mutants with enhanced fitness.Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization.Utility, limitations, and future of non-human primates for dengue research and vaccine developmentFlaviviral RNAs: weapons and targets in the war between virus and host.RNA Structure Duplications and Flavivirus Host Adaptation.Repertoire of virus-derived small RNAs produced by mosquito and mammalian cells in response to dengue virus infection.Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccineAn adjuvanted, tetravalent dengue virus purified inactivated vaccine candidate induces long-lasting and protective antibody responses against dengue challenge in rhesus macaques.Targeted mutagenesis as a rational approach to dengue virus vaccine development.Vaccination of volunteers with low-dose, live-attenuated, dengue viruses leads to serotype-specific immunologic and virologic profilesThe live attenuated chimeric vaccine rWN/DEN4Δ30 is well-tolerated and immunogenic in healthy flavivirus-naïve adult volunteers.Challenges in reducing dengue burden; diagnostics, control measures and vaccines.Recent progress in dengue vaccine development.Expression of dengue-3 premembrane and envelope polyprotein in lettuce chloroplasts.Comparison of full-length genomics sequences between dengue virus serotype 3, parental strain, and its derivatives, and B-cell epitopes prediction from envelope region.Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus.New reverse genetics and transfection methods to rescue arboviruses in mosquito cells.Zika Virus Exhibits Lineage-Specific Phenotypes in Cell Culture, in Aedes aegypti Mosquitoes, and in an Embryo Model.Epitope Sequences in Dengue Virus NS1 Protein Identified by Monoclonal Antibodies
P2860
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P2860
Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4
description
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article scientifique (publié 2008/02/06)
@fr
articolo scientifico (pubblicato il 2008/02/06)
@it
artigo científico (publicado na 2008/02/06)
@pt
artículu científicu espublizáu en 2008
@ast
im Februar 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 6 February 2008)
@en
vedecký článok (publikovaný 2008/02/06)
@sk
vetenskaplig artikel (publicerad på 2008/02/06)
@sv
name
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@ast
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@en
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@nl
type
label
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@ast
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@en
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@nl
prefLabel
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@ast
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@en
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@nl
P2093
P2860
P1433
P1476
Dengue virus type 3 vaccine ca ...... V-3 3′-UTR with that of DENV-4
@en
P2093
Brian R Murphy
Christopher T Hanson
Joseph E Blaney
Kathryn A Hanley
Laura Goddard
Neeraj S Sathe
Tammy A Romero
P2860
P304
P356
10.1016/J.VACCINE.2007.11.082
P407
P577
2008-02-06T00:00:00Z