Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily
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Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies. Alteration of substrate specificity by replacement of Asn149 with AspCrystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesisExpression, purification, assay, and crystal structure of perdeuterated human arginase IA fully automatic evolutionary classification of protein folds: Dali Domain Dictionary version 3Evolution of the arginase fold and functional diversityPhysiological implications of arginine metabolism in plantsHuman ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changesSubunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acidProbing the Specificity Determinants of Amino Acid Recognition by Arginase † ‡Inhibition of human arginase I by substrate and product analoguesCrystal Structure of Arginase from Plasmodium falciparum and Implications for l -Arginine Depletion in Malarial Infection,Guanidine-ferroheme coordination in the mutant protein nitrophorin 4(L130R)Formiminoglutamase from Trypanosoma Cruzi Is An Arginase-Like Manganese MetalloenzymeCrystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of SchistosomiasisYeast epiarginase regulation, an enzyme-enzyme activity control: identification of residues of ornithine carbamoyltransferase and arginase responsible for enzyme catalytic and regulatory activities.Inhibition of rat liver and kidney arginase by cadmium ionCharacterization of Bacillus anthracis arginase: effects of pH, temperature, and cell viability on metal preference.Helicobacter pylori rocF is required for arginase activity and acid protection in vitro but is not essential for colonization of mice or for urease activity.The second-shell metal ligands of human arginase affect coordination of the nucleophile and substrate.Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.Expression, purification and characterization of arginase from Helicobacter pylori in its apo formPharmacophore-based virtual screening to aid in the identification of unknown protein function.The enzymes of β-lactam biosynthesis.Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily.Coagulase-negative Staphylococci favor conversion of arginine into ornithine despite a widespread genetic potential for nitric oxide synthase activity.Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.Crystallization and preliminary crystallographic studies of Helicobacter pylori arginaseEmerging themes in manganese transport, biochemistry and pathogenesis in bacteria.An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channelsSchistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.Structural metal dependency of the arginase from the human malaria parasite Plasmodium falciparum.A combined computational and experimental investigation of the [2Fe-2S] cluster in biotin synthase.Glu-256 is a main structural determinant for oligomerisation of human arginase I.Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling.Regulation of plant arginase by wounding, jasmonate, and the phytotoxin coronatine.Guanidinium export is the primal function of SMR family transporters.Arginase of Helicobacter Gastric Pathogens Uses a Unique Set of Non-catalytic Residues for Catalysis.Biotransformation of L-ornithine from L-arginine using whole-cell recombinant arginase.Development of a multi-enzymatic cascade reaction for the synthesis of trans-3-hydroxy-L-proline from L-arginine.
P2860
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P2860
Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structures of Bacillus ...... is in the arginase superfamily
@ast
Crystal structures of Bacillus ...... is in the arginase superfamily
@en
Crystal structures of Bacillus ...... is in the arginase superfamily
@nl
type
label
Crystal structures of Bacillus ...... is in the arginase superfamily
@ast
Crystal structures of Bacillus ...... is in the arginase superfamily
@en
Crystal structures of Bacillus ...... is in the arginase superfamily
@nl
prefLabel
Crystal structures of Bacillus ...... is in the arginase superfamily
@ast
Crystal structures of Bacillus ...... is in the arginase superfamily
@en
Crystal structures of Bacillus ...... is in the arginase superfamily
@nl
P2093
P1433
P1476
Crystal structures of Bacillus ...... is in the arginase superfamily
@en
P2093
M C Bewley
M L Patchett
P D Jeffrey
P304
P356
10.1016/S0969-2126(99)80056-2
P577
1999-04-01T00:00:00Z