Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
about
A secretory kinase complex regulates extracellular protein phosphorylationErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylationRational approaches to improving selectivity in drug designQuantification of HER family receptors in breast cancerA Raf-induced allosteric transition of KSR stimulates phosphorylation of MEKStructural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 ProteinA Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma VirulenceCrystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617FBiological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective InhibitorsAn Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or NeuregulinMechanism for activation of mutated epidermal growth factor receptors in lung cancerComparative analysis of the Tyr-kinases CapB1 and CapB2 fused to their cognate modulators CapA1 and CapA2 from Staphylococcus aureusStructural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung CancerAn ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 PseudokinaseReceptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells.The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor FamilyStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Pseudokinases: update on their functions and evaluation as new drug targets.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesModel-based analysis of HER activation in cells co-expressing EGFR, HER2 and HER3Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-bindingCo-conserved features associated with cis regulation of ErbB tyrosine kinases.Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121).Yet another "active" pseudokinase, Erb3Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics.Kinase-mediated quasi-dimers of EGFRReceptor tyrosine kinases with intracellular pseudokinase domainsA robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Regulation of the NaV1.5 cytoplasmic domain by calmodulinPharmacological targeting of the pseudokinase Her3Reorienting the Fab domains of trastuzumab results in potent HER2 activators.Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancerERBB3: Multifunctional enabler or primary actor in pancreatic cancer?Inhibiting HER3-mediated tumor cell growth with affibody molecules engineered to low picomolar affinity by position-directed error-prone PCR-like diversificationProfiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology.Mapping C-terminal transactivation domains of the nuclear HER family receptor tyrosine kinase HER3.Carboxyl-group footprinting maps the dimerization interface and phosphorylation-induced conformational changes of a membrane-associated tyrosine kinase.
P2860
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P2860
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural analysis of the cat ...... in of the human EGF receptor 3
@ast
Structural analysis of the cat ...... in of the human EGF receptor 3
@en
Structural analysis of the cat ...... in of the human EGF receptor 3
@nl
type
label
Structural analysis of the cat ...... in of the human EGF receptor 3
@ast
Structural analysis of the cat ...... in of the human EGF receptor 3
@en
Structural analysis of the cat ...... in of the human EGF receptor 3
@nl
prefLabel
Structural analysis of the cat ...... in of the human EGF receptor 3
@ast
Structural analysis of the cat ...... in of the human EGF receptor 3
@en
Structural analysis of the cat ...... in of the human EGF receptor 3
@nl
P2093
P2860
P3181
P356
P1476
Structural analysis of the cat ...... in of the human EGF receptor 3
@en
P2093
David E Shaw
Natalia Jura
Xiaoxian Cao
Yibing Shan
P2860
P304
P3181
P356
10.1073/PNAS.0912101106
P407
P50
P577
2009-12-22T00:00:00Z